Featured Research

from universities, journals, and other organizations

Anything But Modest: The Mouse Continues To Contribute To Humankind

Date:
August 12, 2008
Source:
The Company of Biologists
Summary:
"Big things come in small packages," the saying goes, and it couldn't be more true when discussing the mouse. This little creature has become a crucial part of human history through its contributions in understanding human genetics and disease. In a review published in Disease Models & Mechanisms, genetics researchers from Yale University School of Medicine and Fudan University School of Life Sciences discuss the history and future of mice as a model organism.

"Big things come in small packages," the saying goes, and it couldn't be more true when discussing the mouse. This little creature has become a crucial part of human history through its contributions in understanding human genetics and disease.

Related Articles


In a review published in Disease Models & Mechanisms (DMM), genetics researchers from Yale University School of Medicine and Fudan University School of Life Sciences discuss the history and future of mice as a model organism. They predict that the next frontiers in mouse genetics – such as creating mice expressing human genes to create "humanized" mice – will continue to provide scientists with new tools to not only decipher clinical mysteries, but also to test novel therapies and cures.

The review's authors, Duc Nguyen and Tian Xu, discuss the many ways in which scientists manipulate mouse genes in order to study their biology. One such technique that Nguyen and Xu are working on involves inserting a segment of DNA sequence into the much lengthier full genome of the mouse. These insertable DNA sequences are known as transposons. Use of transposons, as well as other genetic tools, allows scientists to disrupt a specific mouse gene and deduce the gene's function by studying the effect on the mouse. The hope is that the research community can combine the results of extensive mouse studies into a comprehensive library to form a functional map of the mouse genome. Such a map will help researchers navigate and explore the even more extensive human genome to pinpoint the genetic underpinnings of human disease.

Not only do the researchers discuss how mice help us understand disease, but they also highlight methods which enable research of novel disease therapies. For example, humanized mice – mice engineered to carry human genes – can provide new experimental systems for testing new therapeutics.

The full review can be found in the inaugural July/August issue of a new research journal, Disease Models & Mechanisms (DMM), published by The Company of Biologists, a non-profit based in Cambridge, UK.

The DMM website is located at: http://dmm.biologists.org


Story Source:

The above story is based on materials provided by The Company of Biologists. Note: Materials may be edited for content and length.


Journal Reference:

  1. Duc Nguyen, Tian Xu. The expanding role of mouse genetics for understanding human biology and disease. Disease Models and Mechanisms, 2008; 1 (1): 56 DOI: 10.1242/dmm.000232

Cite This Page:

The Company of Biologists. "Anything But Modest: The Mouse Continues To Contribute To Humankind." ScienceDaily. ScienceDaily, 12 August 2008. <www.sciencedaily.com/releases/2008/08/080807130923.htm>.
The Company of Biologists. (2008, August 12). Anything But Modest: The Mouse Continues To Contribute To Humankind. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2008/08/080807130923.htm
The Company of Biologists. "Anything But Modest: The Mouse Continues To Contribute To Humankind." ScienceDaily. www.sciencedaily.com/releases/2008/08/080807130923.htm (accessed October 30, 2014).

Share This



More Plants & Animals News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Galapagos Tortoises Bounce Back, But Ecosystem Lags

Galapagos Tortoises Bounce Back, But Ecosystem Lags

Newsy (Oct. 29, 2014) The Galapagos tortoise has made a stupendous recovery from the brink of extinction to a population of more than 1,000. But it still faces threats. Video provided by Newsy
Powered by NewsLook.com
Obama: The US Will Not 'run and Hide' From Ebola

Obama: The US Will Not 'run and Hide' From Ebola

AP (Oct. 29, 2014) Surrounded by health care workers in the White House East Room, President Barack Obama said the U.S. will likely see additional Ebola cases in the weeks ahead. But he said the nation can't seal itself off in the fight against the disease. (Oct. 29) Video provided by AP
Powered by NewsLook.com
Oatmeal Healthy Recipes and Benefits

Oatmeal Healthy Recipes and Benefits

Buzz60 (Oct. 29, 2014) Oatmeal is a fantastic way to start your day. Whichever way you prepare them, oats provide your body with many health benefits. In celebration of National Oatmeal Day, Krystin Goodwin (@krystingoodwin) has a few recipe ideas, and tips on how to kickstart your day with this wholesome snack! Video provided by Buzz60
Powered by NewsLook.com
GoPro Video Gives a Lion's-Eye View of The Hunt

GoPro Video Gives a Lion's-Eye View of The Hunt

Buzz60 (Oct. 29, 2014) If you’ve ever wondered what getting takeout looks like for lions in Africa, the GoPro video from Lion Whisperer Kevin Richardson will give you a lion’s-eye view of the hunt. Jen Markham has more. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins