Featured Research

from universities, journals, and other organizations

Gene For Day Blindness In Dachshunds Found

Date:
June 2, 2009
Source:
Norwegian School of Veterinary Science
Summary:
Researchers have discovered the genetic cause of day blindness or "cone-rod dystrophy" in the wire-haired dachshund. The disease was discovered in two litter mates in 1999 and has since been studied in both clinical and genetic trials in offspring of these.

Wire-haired dachshund suffering from the disease has a bad eyesight in daylignt and becomes gradually blind.
Credit: Photo by Frode Lingaas

A PhD project by Anne Caroline Wiik has discovered the genetic cause of day blindness or "cone-rod dystrophy” in the wire-haired dachshund. The disease was discovered in two litter mates in 1999 and has since been studied in both clinical and genetic trials in offspring of these.

Related Articles


In her thesis, Anne Caroline Wiik concentrated on finding the genetic mutation that causes this disease. Day blindness is a recessive, heritable disease in which both parents need to be carriers in order for the disease to develop.

Inherited photoreceptor diseases, or diseases in the sensory cells of the retina (rods and cones), occur naturally in both animals and man. They comprise the most common form of inherited retinal disease in people, with an occurrence of approximately 1 in 4,000.

The project began with a candidate gene study, in which genes known to cause similar diseases in people were investigated to see if they had any connection to the canine disease. Ten genes were studied, without a connection being found between the genes and eye disease.

A new method for finding genetic mutations

Wiik was then among the first researchers to be given an opportunity to try a new method of finding genes causing the disease in dogs. By comparing all genes in a sample of sick and healthy dogs, an area that might contain the diseased gene was isolated. Some seventy separate genes occurred within this particular region, and the most likely were studied more closely in the hunt for damaging mutations.

Part of the gene NPHP4 (Nephronophthisis 4) was shown to be lacking in the sick dogs. This genetic mutation leads to the dog losing important functions, which especially affects the cones of the eye, and eventually also the rods.

A series of dachshunds were subsequently tested for the mutation. Gene-testing of wire-haired dachshunds showed that some 9.8% of the dogs carried the mutation, which seems to have appeared around 1970. With such a high percentage of the dachshund population affected, the risk that two randomly chosen dogs will both be carriers is quite high, and a genetic test is now available to reduce the possibility of the disease appearing in more litters.

Cand. Scient. Anne Caroline Wiik defended her PhD thesis, entitled "Genetic studies of cone-rod dystrophy in the standard wire-haired dachshund", at the Norwegian School of Veterinary Science, on May 13, 2009.


Story Source:

The above story is based on materials provided by Norwegian School of Veterinary Science. Note: Materials may be edited for content and length.


Cite This Page:

Norwegian School of Veterinary Science. "Gene For Day Blindness In Dachshunds Found." ScienceDaily. ScienceDaily, 2 June 2009. <www.sciencedaily.com/releases/2009/06/090602083759.htm>.
Norwegian School of Veterinary Science. (2009, June 2). Gene For Day Blindness In Dachshunds Found. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2009/06/090602083759.htm
Norwegian School of Veterinary Science. "Gene For Day Blindness In Dachshunds Found." ScienceDaily. www.sciencedaily.com/releases/2009/06/090602083759.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
New Fish Species Discovered, Setting Record for World's Deepest

New Fish Species Discovered, Setting Record for World's Deepest

Buzz60 (Dec. 22, 2014) A new species of fish is discovered living five miles beneath the ocean surface, making it the deepest living fish on earth. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins