Featured Research

from universities, journals, and other organizations

Scientists Uncork Potential Secret Of Red Wine's Health Benefits

Date:
August 3, 2009
Source:
Federation of American Societies for Experimental Biology
Summary:
Scientists have unraveled a mystery that has perplexed scientists since red wine was first discovered to have health benefits: How does resveratrol control inflammation? New research not only explains resveratrol's one-two punch on inflammation, but also show how it -- or a derivative -- can be used to treat potentially deadly inflammatory disease, such as appendicitis, peritonitis and systemic sepsis.

Scientists have unraveled a mystery that has perplexed scientists since red wine was first discovered to have health benefits: how does resveratrol control inflammation?
Credit: iStockphoto/Ina Peters

Scientists from Scotland and Singapore have unraveled a mystery that has perplexed scientists since red wine was first discovered to have health benefits: how does resveratrol control inflammation? New research published in the August 2009 print issue of The FASEB Journal, not only explains resveratrol's one-two punch on inflammation, but also show how it—or a derivative—can be used to treat potentially deadly inflammatory disease, such as appendicitis, peritonitis, and systemic sepsis.

"Strong acute inflammatory diseases such as sepsis are very difficult to treat and many die every day due to lack of treatment," said Alirio Melendez, senior lecturer on the faculty of medicine at Glasgow Biomedical Research Centre in Scotland and one of the researchers involved in the work. "Moreover, many survivors of sepsis develop a very low quality of life due to the damage that inflammation causes to several internal organs. The ultimate goal of our study was to identify a potential novel therapy to help in the treatment of strong acute inflammatory diseases."

In this study, researchers administered an inflammatory agent to two groups of mice. One group was pretreated with resveratrol and the other group was not. The mice that were not pretreated with resveratrol experienced a strong inflammatory response, simulating disease in humans, while the group pretreated with resveratrol was protected from the inflammation. The scientists then examined the tissues of the mice to determine exactly how resveratrol was able to protect the mice from inflammation. They found that resveratrol used a one-two punch to stop inflammation in the mice by preventing the body from creating two different molecules known to trigger inflammation, sphingosine kinase and phospholipase D. This finding suggests that resveratrol may be harnessable as a treatment for inflammatory diseases and may also lead to entirely new resveratrol-based drugs that are even more effective.

"The therapeutic potential of red wine has been bottled up for thousands of years," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal, "and now that scientists have uncorked its secrets, they find that studies of how resveratrol works can lead to new treatments for life-threatening inflammation."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Issuree et al. Resveratrol attenuates C5a-induced inflammatory responses in vitro and in vivo by inhibiting phospholipase D and sphingosine kinase activities. The FASEB Journal, 2009; 23 (8): 2412 DOI: 10.1096/fj.09-130542

Cite This Page:

Federation of American Societies for Experimental Biology. "Scientists Uncork Potential Secret Of Red Wine's Health Benefits." ScienceDaily. ScienceDaily, 3 August 2009. <www.sciencedaily.com/releases/2009/07/090730103742.htm>.
Federation of American Societies for Experimental Biology. (2009, August 3). Scientists Uncork Potential Secret Of Red Wine's Health Benefits. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2009/07/090730103742.htm
Federation of American Societies for Experimental Biology. "Scientists Uncork Potential Secret Of Red Wine's Health Benefits." ScienceDaily. www.sciencedaily.com/releases/2009/07/090730103742.htm (accessed October 1, 2014).

Share This



More Plants & Animals News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Attacking Superbugs

Attacking Superbugs

Ivanhoe (Oct. 1, 2014) — Two weapons hospitals can use to attack superbugs. Scientists in Ireland created a new gel resistant to superbugs, and a robot that can disinfect a room in minutes. Video provided by Ivanhoe
Powered by NewsLook.com
Cultural Learning In Wild Chimps Observed For The First Time

Cultural Learning In Wild Chimps Observed For The First Time

Newsy (Oct. 1, 2014) — Cultural transmission — the passing of knowledge from one animal to another — has been caught on camera with chimps teaching other chimps. Video provided by Newsy
Powered by NewsLook.com
Earth Has Lost Half Its Vertebrate Wildlife Since 1970: WWF

Earth Has Lost Half Its Vertebrate Wildlife Since 1970: WWF

Newsy (Sep. 30, 2014) — A new study published by the World Wide Fund for Nature found that more than half of the world's wildlife population has declined since 1970. Video provided by Newsy
Powered by NewsLook.com
Annual Dog Surfing Competition Draws California Crowds

Annual Dog Surfing Competition Draws California Crowds

AFP (Sep. 30, 2014) — The best canine surfers gathered for Huntington Beach's annual dog surfing competition, "Surf City, Surf Dog." Duration: 01:15 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins