Featured Research

from universities, journals, and other organizations

New finding in ribosome signaling may lead to improved antibiotics

Date:
February 24, 2011
Source:
University of Illinois at Chicago
Summary:
Researchers have discovered a signaling mechanism in the bacterial ribosome that detects proteins that activate genes for antibiotic resistance.

Researchers at the University of Illinois at Chicago have discovered a signaling mechanism in the bacterial ribosome that detects proteins that activate genes for antibiotic resistance.

"The ribosome is one of the most complex molecular machines in the cell," said Alexander Mankin, UIC professor and director of the Center for Pharmaceutical Biotechnology. It is responsible for the production of all proteins in the cell, and in bacteria it is one of the major antibiotic targets.

Understanding how signals are generated and transmitted within the ribosome, Mankin said, may one day lead to better antibiotics.

Mankin's research, funded by the National Science Foundation, has been published in the journal Molecular Cell.

The ribosome is responsible for activating some antibiotic resistance genes in the presence of certain proteins. For that to occur, special sensors in the ribosome must recognize cellular cues and the structure of the regulatory protein. Once the signal is detected, it is then transmitted to the functional centers which alter the ribosome's performance.

Mankin's latest research has found at least one of the signal pathways in the ribosome. He and his coworkers found that the presence of the regulatory protein as it is made within the ribosome changes the properties of the ribosome's catalytic center.

Under normal conditions, the ribosome's catalytic center can accept any of the 20 natural amino acids, which are then added to the growing protein chain.

However, if the ribosome has synthesized the regulatory protein in the presence of an antibiotic, the catalytic center rejects some or even all amino acids. As a result, synthesis of the regulatory protein stops, and the genes of antibiotic resistance are activated.

"This is one of the strategies used by pathogenic bacteria exposed to antibiotics to regulate expression of antibiotic resistance genes," Mankin said.

In previous studies, Mankin and his research team pinpointed some of the ribosomal RNA residues that interact with the growing regulatory peptide, thus serving the function of the peptide sensors.

Mankin and his research team -- Haripriya Ramu, Nora Vazquez-Laslop and Dorota Klepacki -- was assisted by Qing Dai and Joseph Piccirilli, of the University of Chicago and Ronald Micura of the University of Innsbruck in Austria.


Story Source:

The above story is based on materials provided by University of Illinois at Chicago. Note: Materials may be edited for content and length.


Journal Reference:

  1. Haripriya Ramu, Nora Vázquez-Laslop, Dorota Klepacki, Qing Dai, Joseph Piccirilli, Ronald Micura, Alexander S. Mankin. Nascent Peptide in the Ribosome Exit Tunnel Affects Functional Properties of the A-Site of the Peptidyl Transferase Center. Molecular Cell, 2011; 41 (3): 321 DOI: 10.1016/j.molcel.2010.12.031

Cite This Page:

University of Illinois at Chicago. "New finding in ribosome signaling may lead to improved antibiotics." ScienceDaily. ScienceDaily, 24 February 2011. <www.sciencedaily.com/releases/2011/02/110223092404.htm>.
University of Illinois at Chicago. (2011, February 24). New finding in ribosome signaling may lead to improved antibiotics. ScienceDaily. Retrieved September 1, 2014 from www.sciencedaily.com/releases/2011/02/110223092404.htm
University of Illinois at Chicago. "New finding in ribosome signaling may lead to improved antibiotics." ScienceDaily. www.sciencedaily.com/releases/2011/02/110223092404.htm (accessed September 1, 2014).

Share This




More Plants & Animals News

Monday, September 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) — A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Washington Wildlife Center Goes Nuts Over Baby Squirrels

Washington Wildlife Center Goes Nuts Over Baby Squirrels

Reuters - US Online Video (Aug. 30, 2014) — An animal rescue in Washington state receives an influx of orphaned squirrels, keeping workers busy as they nurse them back to health. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Experimental Ebola Drug ZMapp Cures Lab Monkeys Of Disease

Experimental Ebola Drug ZMapp Cures Lab Monkeys Of Disease

Newsy (Aug. 29, 2014) — In a new study, a promising experimental treatment for Ebola managed to cure a group of infected macaque monkeys. Video provided by Newsy
Powered by NewsLook.com
Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) — State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins