Featured Research

from universities, journals, and other organizations

Cancer Genome Atlas completes detailed ovarian cancer analysis

Date:
June 30, 2011
Source:
University of North Carolina School of Medicine
Summary:
As part of the Cancer Genome Atlas project, North Carolina researchers have contributed to the most comprehensive an integrated view of cancer genes for any cancer type produced to date.

As part of The Cancer Genome Atlas (TCGA) project, UNC Lineberger researchers have contributed to the most comprehensive and integrated view of cancer genes for any cancer type produced to date.

The UNC team, which includes Charles Perou, PhD, professor of pathology and laboratory medicine and genetics, Neil Hayes, MD, associate professor of hematology/oncology, and Katie Hoadley, PhD, Research Associate, completed the microRNA and mRNA microarray analysis that contributed to the findings.

Ovarian serous adenocarcinoma tumors from 500 patients were examined and the analyses are reported in the June 30, 2011 issue of the journal Nature. Serous adenocarcinoma accounts for about 85 percent of all ovarian cancer deaths.

The researchers confirmed that mutations in the tumor suppressor gene TP53, are present in more than 96 percent of these cancers. Tumor suppressor genes produce proteins that normally prevent cancer formation. When the genes mutate and those protein functions are disrupted, tumors can form.

The team also found sets of genes associated with different patient survival patterns, identifying a set of 108 genes associated with poor survival and 85 genes associated with better survival. Overall, the five-year survival rate for ovarian cancer is 31 percent, meaning that there is an urgent need for a better understanding of and therapeutic targets for the disease.

"These are exactly the types of cancers for which The Cancer Genome Atlas project can make a difference, providing the resources and collaborative scientific power to establish new investigative avenues aimed at treatments targeted to the specific biology of ovarian cancer," said Hayes.

Investigators on the project also searched for existing drugs that might inhibit genes that seem to play a role in ovarian cancer. They identified 68 genes that could be targeted by existing FDA-approved or experimental therapeutic compounds. For example, PARP inhibitors, which have been tested in clinical trials at UNC and elsewhere, may be able to counteract a DNA repair gene observed in half of the ovarian tumors studied.

TCGA is jointly funded and managed by the National Cancer Institute (NCI) and the National Human Genome Research Institute (NHGRI), both part of the National Institutes of Health. As participants in TCGA, UNC Lineberger scientists have also been involved in findings related to subtypes of the brain tumor glioblastoma and of lung cancers.


Story Source:

The above story is based on materials provided by University of North Carolina School of Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. Bell et al. Integrated genomic analyses of ovarian carcinoma. Nature, 2011; 474 (7353): 609 DOI: 10.1038/nature10166

Cite This Page:

University of North Carolina School of Medicine. "Cancer Genome Atlas completes detailed ovarian cancer analysis." ScienceDaily. ScienceDaily, 30 June 2011. <www.sciencedaily.com/releases/2011/06/110630131834.htm>.
University of North Carolina School of Medicine. (2011, June 30). Cancer Genome Atlas completes detailed ovarian cancer analysis. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2011/06/110630131834.htm
University of North Carolina School of Medicine. "Cancer Genome Atlas completes detailed ovarian cancer analysis." ScienceDaily. www.sciencedaily.com/releases/2011/06/110630131834.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins