Featured Research

from universities, journals, and other organizations

New way to form extracellular vesicles

Date:
November 21, 2011
Source:
NYU Langone Medical Center / New York University School of Medicine
Summary:
Researchers have discovered a protein called TAT-5 that affects the production of extracellular vesicles, small sacs of membrane released from the surface of cells, capable of sending signals to other cells.

Researchers at NYU Langone Medical Center have discovered a protein called TAT-5 that affects the production of extracellular vesicles, small sacs of membrane released from the surface of cells, capable of sending signals to other cells. When released extracellular vesicles can affect tumor spread, blood clotting and inflammation. Their discovery gives new insight into how extracellular vesicles form, and reveals new potential strategies to manipulate diseases such as cancer.

The study was published online November 17, 2011 in Current Biology.

"Very little is known about how cells release extracellular vesicles from their surfaces, so the discovery of TAT-5 opens the door to learning how to manipulate their numbers and thus affect cell communication," said Jeremy Nance, PhD, associate professor of Cell Biology at NYU School of Medicine and a member of the Developmental Genetics Program at the Skirball Institute of Biomolecular Medicine.

Researchers at NYU Langone studied the embryo of the worm C. elegans and discovered that TAT-5 inhibits the budding of extracellular vesicles from the surface of cells. Several types of tumors produce extracellular vesicles that can induce tumor cell invasion or metastasis. Researchers found they can use tat-5 mutants as a tool to study how extracellular vesicles are formed, enabling the design of strategies to regulate their formation. In the study, researchers also discovered that two proteins that regulate viral budding are involved in extracellular vesicle release, suggesting that budding of viruses and release of extracellular vesicles might occur through similar mechanisms, and that this research may reveal new strategies to inhibit viral spread.


Story Source:

The above story is based on materials provided by NYU Langone Medical Center / New York University School of Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ann M. Wehman, Corey Poggioli, Peter Schweinsberg, Barth D. Grant, Jeremy Nance. The P4-ATPase TAT-5 Inhibits the Budding of Extracellular Vesicles in C. elegans Embryos. Current Biology, 17 November 2011 DOI: 10.1016/j.cub.2011.10.040

Cite This Page:

NYU Langone Medical Center / New York University School of Medicine. "New way to form extracellular vesicles." ScienceDaily. ScienceDaily, 21 November 2011. <www.sciencedaily.com/releases/2011/11/111117141249.htm>.
NYU Langone Medical Center / New York University School of Medicine. (2011, November 21). New way to form extracellular vesicles. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2011/11/111117141249.htm
NYU Langone Medical Center / New York University School of Medicine. "New way to form extracellular vesicles." ScienceDaily. www.sciencedaily.com/releases/2011/11/111117141249.htm (accessed April 20, 2014).

Share This



More Plants & Animals News

Sunday, April 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mich. Boy Unearths 10,000-Year-Old Mastodon Tooth

Mich. Boy Unearths 10,000-Year-Old Mastodon Tooth

Newsy (Apr. 20, 2014) A 9-year-old Michigan boy was exploring a creek when he came across a 10,000-year-old tooth from a prehistoric mastodon. Video provided by Newsy
Powered by NewsLook.com
Vermont Goat Meat Gives Refugees Taste of Home

Vermont Goat Meat Gives Refugees Taste of Home

AP (Apr. 18, 2014) Dairy farmers and ethnic groups in Vermont are both benefiting from a unique collaborative effort that's feeding a growing need for fresh and affordable goat meat. (April 18) Video provided by AP
Powered by NewsLook.com
Man Claims He Found Loch Ness Monster With... Apple Maps?

Man Claims He Found Loch Ness Monster With... Apple Maps?

Newsy (Apr. 18, 2014) Andy Dixon showed the Daily Mail a screenshot of what he believes to be the mythical beast swimming just below the lake's surface. Video provided by Newsy
Powered by NewsLook.com
First Ever 'Female Penis' Discovered In Animal Kingdom

First Ever 'Female Penis' Discovered In Animal Kingdom

Newsy (Apr. 18, 2014) Not only are these newly discovered bugs' sex organs reversed, but they also mate for up to 70 hours. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins