Featured Research

from universities, journals, and other organizations

New way to form extracellular vesicles

Date:
November 21, 2011
Source:
NYU Langone Medical Center / New York University School of Medicine
Summary:
Researchers have discovered a protein called TAT-5 that affects the production of extracellular vesicles, small sacs of membrane released from the surface of cells, capable of sending signals to other cells.

Researchers at NYU Langone Medical Center have discovered a protein called TAT-5 that affects the production of extracellular vesicles, small sacs of membrane released from the surface of cells, capable of sending signals to other cells. When released extracellular vesicles can affect tumor spread, blood clotting and inflammation. Their discovery gives new insight into how extracellular vesicles form, and reveals new potential strategies to manipulate diseases such as cancer.

The study was published online November 17, 2011 in Current Biology.

"Very little is known about how cells release extracellular vesicles from their surfaces, so the discovery of TAT-5 opens the door to learning how to manipulate their numbers and thus affect cell communication," said Jeremy Nance, PhD, associate professor of Cell Biology at NYU School of Medicine and a member of the Developmental Genetics Program at the Skirball Institute of Biomolecular Medicine.

Researchers at NYU Langone studied the embryo of the worm C. elegans and discovered that TAT-5 inhibits the budding of extracellular vesicles from the surface of cells. Several types of tumors produce extracellular vesicles that can induce tumor cell invasion or metastasis. Researchers found they can use tat-5 mutants as a tool to study how extracellular vesicles are formed, enabling the design of strategies to regulate their formation. In the study, researchers also discovered that two proteins that regulate viral budding are involved in extracellular vesicle release, suggesting that budding of viruses and release of extracellular vesicles might occur through similar mechanisms, and that this research may reveal new strategies to inhibit viral spread.


Story Source:

The above story is based on materials provided by NYU Langone Medical Center / New York University School of Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ann M. Wehman, Corey Poggioli, Peter Schweinsberg, Barth D. Grant, Jeremy Nance. The P4-ATPase TAT-5 Inhibits the Budding of Extracellular Vesicles in C. elegans Embryos. Current Biology, 17 November 2011 DOI: 10.1016/j.cub.2011.10.040

Cite This Page:

NYU Langone Medical Center / New York University School of Medicine. "New way to form extracellular vesicles." ScienceDaily. ScienceDaily, 21 November 2011. <www.sciencedaily.com/releases/2011/11/111117141249.htm>.
NYU Langone Medical Center / New York University School of Medicine. (2011, November 21). New way to form extracellular vesicles. ScienceDaily. Retrieved August 2, 2014 from www.sciencedaily.com/releases/2011/11/111117141249.htm
NYU Langone Medical Center / New York University School of Medicine. "New way to form extracellular vesicles." ScienceDaily. www.sciencedaily.com/releases/2011/11/111117141249.htm (accessed August 2, 2014).

Share This




More Plants & Animals News

Saturday, August 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pyrenees Orphan Bear Cub Gets Brand New Home

Pyrenees Orphan Bear Cub Gets Brand New Home

AFP (Aug. 1, 2014) The discovery of a bear cub in the Pyrenees mountains made headlines in April 2014. Despire several attempts to find the animal's mother, the cub remained alone. Now, the Pyrenees Conservation Foundation has constructed an enclosure. Duration: 00:31 Video provided by AFP
Powered by NewsLook.com
Ebola Vaccine Might Be Coming, But Where's It Been?

Ebola Vaccine Might Be Coming, But Where's It Been?

Newsy (Aug. 1, 2014) Health officials are working to fast-track a vaccine — the West-African Ebola outbreak has killed more than 700. But why didn't we already have one? Video provided by Newsy
Powered by NewsLook.com
Study Links Certain Birth Control Pills To Breast Cancer

Study Links Certain Birth Control Pills To Breast Cancer

Newsy (Aug. 1, 2014) Previous studies have made the link between birth control and breast cancer, but the latest makes the link to high-estrogen oral contraceptives. Video provided by Newsy
Powered by NewsLook.com
Rare Whale Fossil Pulled from Calif. Backyard

Rare Whale Fossil Pulled from Calif. Backyard

AP (Aug. 1, 2014) A rare whale fossil has been pulled from a Southern California backyard. The 16- to 17-million-year-old baleen whale fossil is one of about 20 baleen whale fossils known to exist. (Aug. 1) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins