Featured Research

from universities, journals, and other organizations

Research on pigeon color reveals mutation hotspot

Date:
February 6, 2014
Source:
University of Texas at Arlington
Summary:
Researchers have examined three genes that control multiple color phenotypes, or appearances, in pigeons. The UT Arlington team found two independent deletions of regulatory sequences near the Sox10 gene produce "recessive red" pigmentation. These mutations happened at different points in evolution, and researchers believe it is no coincidence they hit the same spot.

Pigeons aren't quite this colorful, but there are a wide variety of appearances. Geneticists looking at the genes that underlie color combinations have published their work in Current Biology.
Credit: John W. Fondon, UT Arlington

A University of Texas at Arlington team exploring pigeons as a model for vertebrate evolution has uncovered that mutations and interactions among just three genes create a wide variety of color variations. One of those genes, they also found, may be an example of a "slippery gene" more prone to evolutionary changes.

John W. "Trey" Fondon, an assistant professor of biology, is co-author of a study that begins to unravel the molecular basis for the color palette of domestic pigeons breeds known as "fancy pigeons." Due mostly to organized breeding in Europe and Asia, there are hundreds of types of pigeons that have evolved to include numerous color variations on the blue/black model, including shades of gray, red, and brown.

The genes in the study have previously been linked to skin and hair color variation among people, as well as the development of melanoma.

"The pigeon really has been neglected as a model system, and we are changing that," Fondon said, adding that such studies can help in an overall understanding of vertebrate systems. "The things that shape diversity also shape disease."

The results are being published online Feb. 6 in the journal Current Biology. Eric T. Domyan, a post-doctoral fellow in the lab of University of Utah professor Michael D. Shapiro, is lead author.

Other co-authors include Shapiro; Shreyas Krishnan and Clifford Rodgers, of UT Arlington; Zev Kronenberg, Michael W. Guernsey, Anna Vickery and Mark Yandell, of University of Utah; Raymond E. Boissy, of the University of Cincinnati College of Medicine; and Pamela Cassidy and Sancy A. Leachman, of the Oregon Health & Science University.

Shapiro's team at University of Utah published research last year in the journal Science that revealed results from the first large-scale sequencing of the pigeon genome. That collection of DNA from 40 pigeons, provided the basis for the new work.

Geneticists like Fondon have turned to dog breeds in the past to understand the molecular basis of phenotype changes because dog breeds are so varied. Fondon said scientists hoping to understand more about how characteristics vary can find even greater statistical power and diversity in studying domestic pigeons.

Fondon's laboratory worked in parallel with researchers at Utah to find that coding and regulatory variations in the interactions among the genes Tyrp1, Sox10 and Slc45a2 control multiple color phenotypes, or appearances, in pigeons. For example, researchers found that the ash-red mutation in Tyrp1, a gene that plays a large role in color determination, arose just once and was spread throughout the species by selective breeding.

They also found that some color changes evolved through changes in the same gene that happened at different times -- hinting at the existence of a "slippery gene."

Fondon's team found two independent deletions of regulatory sequences near the Sox10 gene produce "recessive red" pigmentation. These mutations happened at different points in evolution, and researchers believe it is no coincidence they hit the same spot, as this same region is also deleted in color mutants of chickens and mice, Fondon said. There are indications of yet more independent mutations of this "hotspot."

More research is needed, but Fondon expects significant progress in understanding is on the horizon.

"These traits are falling like dominoes in terms of our understanding their genetic origins. It took hundreds of years to set them up and now they are just falling," Fondon said.

The name of the new paper is "Epistatic and combinatorial effects of pigmentary gene mutations in the domestic pigeon."

"Dr. Fondon is contributing important, essential discoveries to our understanding of how genes change over time. His work is strengthening our already vibrant Genome Biology Group and the College of Science overall," said Pamela Jansma, dean of the UT Arlington College of Science.


Story Source:

The above story is based on materials provided by University of Texas at Arlington. Note: Materials may be edited for content and length.


Journal Reference:

  1. Eric T. Domyan, Michael W. Guernsey, Zev Kronenberg, Shreyas Krishnan, Raymond E. Boissy, Anna I. Vickrey, Clifford Rodgers, Pamela Cassidy, Sancy A. Leachman, John W. Fondon, Mark Yandell, Michael D. Shapiro. Epistatic and Combinatorial Effects of Pigmentary Gene Mutations in the Domestic Pigeon. Current Biology, 2014; DOI: 10.1016/j.cub.2014.01.020

Cite This Page:

University of Texas at Arlington. "Research on pigeon color reveals mutation hotspot." ScienceDaily. ScienceDaily, 6 February 2014. <www.sciencedaily.com/releases/2014/02/140206133820.htm>.
University of Texas at Arlington. (2014, February 6). Research on pigeon color reveals mutation hotspot. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2014/02/140206133820.htm
University of Texas at Arlington. "Research on pigeon color reveals mutation hotspot." ScienceDaily. www.sciencedaily.com/releases/2014/02/140206133820.htm (accessed August 21, 2014).

Share This




More Plants & Animals News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Possible Ebola Patient in Isolation at California Hospital

Possible Ebola Patient in Isolation at California Hospital

Reuters - US Online Video (Aug. 20, 2014) — A patient who may have been exposed to the Ebola virus is in isolation at the Kaiser Permanente South Sacramento Medical Center. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Flower Power! Dandelions Make Car Tires?

Flower Power! Dandelions Make Car Tires?

Reuters - Business Video Online (Aug. 20, 2014) — Forget rolling on rubber, could car drivers soon be traveling on tires made from dandelions? Teams of scientists are racing to breed a type of the yellow flower whose taproot has a milky fluid with tire-grade rubber particles in it. As Joanna Partridge reports, global tire makers are investing millions in research into a new tire source. Video provided by Reuters
Powered by NewsLook.com
Unsustainable Elephant Poaching Killed 100K In 3 Years

Unsustainable Elephant Poaching Killed 100K In 3 Years

Newsy (Aug. 20, 2014) — Poachers have killed 100,000 elephants between 2010 and 2012, as the booming ivory trade takes its toll on the animals in Africa. Video provided by Newsy
Powered by NewsLook.com
Awesome New Camouflage Sheet Was Inspired By Octopus Skin

Awesome New Camouflage Sheet Was Inspired By Octopus Skin

Newsy (Aug. 19, 2014) — Scientists have developed a new device that mimics the way octopuses blend in with their surroundings to hide from dangerous predators. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

More Coverage


Birds of a Different Color: Three Major Genes Set Feather Hue in Pigeons

Feb. 6, 2014 — Scientists have identified mutations in three key genes that determine feather color in domestic rock pigeons. The same genes control pigmentation of human skin and can be responsible for melanoma ... read more
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins