Featured Research

from universities, journals, and other organizations

Tibetan mastiffs equally adapted to high altitudes of Tibet

Date:
February 11, 2014
Source:
Molecular Biology and Evolution (Oxford University Press)
Summary:
In a new study published in the journal Molecular Biology and Evolution, author Dong-Dong Wu, et. al., explored the genetic basis of high-altitude adaptation of Tibetan Mastiffs, which were originally domesticated from the Chinese native dogs of the plains. Overall, they identified more than 120,000 SNPs, and in their analysis, narrowed these down to 16 genes that have undergone positive selection in mastiffs, with 12 of these relevant to high altitude adaption.

Tibetan mastiff.
Credit: zuzule / Fotolia

As humans have expanded into new environments and civilizations, man's best friend, dogs, have been faithful companions at their sides. Now, with DNA sequencing technology readily available to examine the dog genome, scientists are gaining new insights into canine evolution.

Related Articles


In a new study published in the journal Molecular Biology and Evolution, author Dong-Dong Wu, et. al., explored the genetic basis of high-altitude adaptation of Tibetan Mastiffs, which were originally domesticated from the Chinese native dogs of the plains. The authors examined genome-wide mutations (called single nucleotide polymorphisms, or SNPs) of 32 Tibetan Mastiffs, and compared them to 20 Chinese native dogs and 14 grey wolves. Overall, they identified more than 120,000 SNPs, and in their analysis, narrowed these down to 16 genes that have undergone positive selection in mastiffs, with 12 of these relevant to high altitude adaption.

These candidate genes have been shown to be involved in energy production critical to high-altitude survival under low oxygen conditions. Similar categories showing selective signatures have been observed in other high-altitude animals, suggesting that "independently, genes can be adaptively evolved to yield similar phenotypic adaptive responses," said Wu

One hypoxia-inducible factor (HIFs), called EPAS1, has also been found in hypoxia adaptation in Tibetans, supporting the possibility of convergent evolution occurring between dogs and humans, though the authors caution that much more work needs to be done for a full comparison of high altitude adaptation. For future studies, the authors will explore using whole genome sequences from individual Tibetan Mastiffs to gain better insights into high-altitude adaptations and canine evolution.


Story Source:

The above story is based on materials provided by Molecular Biology and Evolution (Oxford University Press). Note: Materials may be edited for content and length.


Journal Reference:

  1. Yan Li, Dong-Dong Wu, Adam R. Boyko, Guo-Dong Wang, Shi-Fang Wu, David M Irwin, and Ya-Ping Zhang. Population variation revealed high altitude adaptation of Tibetan Mastiffs. Mol Biol Evol, February 11, 2014 DOI: 10.1093/molbev/msu070

Cite This Page:

Molecular Biology and Evolution (Oxford University Press). "Tibetan mastiffs equally adapted to high altitudes of Tibet." ScienceDaily. ScienceDaily, 11 February 2014. <www.sciencedaily.com/releases/2014/02/140211174803.htm>.
Molecular Biology and Evolution (Oxford University Press). (2014, February 11). Tibetan mastiffs equally adapted to high altitudes of Tibet. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2014/02/140211174803.htm
Molecular Biology and Evolution (Oxford University Press). "Tibetan mastiffs equally adapted to high altitudes of Tibet." ScienceDaily. www.sciencedaily.com/releases/2014/02/140211174803.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Classic Hollywood Memorabilia Goes Under the Hammer

Classic Hollywood Memorabilia Goes Under the Hammer

Reuters - Entertainment Video Online (Nov. 26, 2014) The iconic piano from "Casablanca" and the Cowardly Lion suit from "The Wizard of Oz" fetch millions at auction. Sara Hemrajani reports. Video provided by Reuters
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Feast Your Eyes: Lamb Chop Sent Into Space from UK

Feast Your Eyes: Lamb Chop Sent Into Space from UK

Reuters - Light News Video Online (Nov. 25, 2014) Take a stab at this -- stunt video shows a lamb chop's journey from an east London restaurant over 30 kilometers into space. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins