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Temperature Sensing By The Circadian Clock

Date:
August 24, 2005
Source:
Cold Spring Harbor Laboratory
Summary:
Dr. Michael Brunner and colleagues have uncovered the molecular mechanism whereby temperature affects circadian patterns in the fungus Neurospora.
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In the September 1 issue of G&D, Dr. Michael Brunner and colleagueshave uncovered the molecular mechanism whereby temperature affectscircadian patterns in the fungus Neurospora. The scientistsinvestigated thermosensitive splicing of the central clockwork protein,FREQUENCY (FRQ), into both long (l) and short (s) isoforms dependingupon temperature.

They found that at low temperatures, intron 6 of frq mRNA ispreferentially spliced, resulting in the exclusion of the l-FRQtranslation initiation site.

This mechanism works alongside atemperature-dependent inhibition of translation by uORFs to effectivelymodulate FRQ levels -- and thereby circadian rhythmicity -- withchanges in ambient temperature.

Dr. Brunner emphasizes that the"interaction of molecular machinery with non-consensus signals - inthis case the interaction of splicing machinery with non-consensussplice sites and the interaction of ribosomes with non-consensustranslation initiation sites - may provide a general mechanism fortemperature-sensing on the molecular level."


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Materials provided by Cold Spring Harbor Laboratory. Note: Content may be edited for style and length.


Cite This Page:

Cold Spring Harbor Laboratory. "Temperature Sensing By The Circadian Clock." ScienceDaily. ScienceDaily, 24 August 2005. <www.sciencedaily.com/releases/2005/08/050824081939.htm>.
Cold Spring Harbor Laboratory. (2005, August 24). Temperature Sensing By The Circadian Clock. ScienceDaily. Retrieved February 26, 2024 from www.sciencedaily.com/releases/2005/08/050824081939.htm
Cold Spring Harbor Laboratory. "Temperature Sensing By The Circadian Clock." ScienceDaily. www.sciencedaily.com/releases/2005/08/050824081939.htm (accessed February 26, 2024).

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