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Fishing For Alternatives: Cultured Cell Lines And Organs Used To Help Study Effects Of Toxins

Date:
April 4, 2007
Source:
Society for Experimental Biology
Summary:
Cultured fish cell lines and organs such as gills, heart, liver and intestines are being used to investigate the effects of toxins on fish such as freshwater trout and carp in a move to cut down the number of experiments carried out on live fish.
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Cultured fish cell lines and organs such as gills, heart, liver and intestines are being used to investigate the effects of toxins on fish such as freshwater trout and carp in a move to cut down the number of experiments carried out on live fish.

Fish Biologists presented new culture methods to help replace the use of live fish for safety testing of chemicals in Glasgow for the Annual Main Meeting of the Society for Experimental Biology on April 1, 2007.

The move is in response to a European Commission directive to replace the use of animals in ecotoxicology which has seen the establishment of a European Centre for Validation of Alternative Methods (ECVAM) Taskforce composed of Commission and non-Commission experts giving scientific advice on 3Rs methods and testing strategies.

As an example, Dr Richard Handy at the University of Plymouth has developed a perfusion method where he can dose particular fish organs with various levels of chemicals to identify the role of a particular organ when it is presented with different toxins.

"We have been able to measure the effects of toxins such as cyanide, copper and mercury on uptake into the catfish intestine", says Dr Handy who is organising this session at the SEB Meeting.


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Cite This Page:

Society for Experimental Biology. "Fishing For Alternatives: Cultured Cell Lines And Organs Used To Help Study Effects Of Toxins." ScienceDaily. ScienceDaily, 4 April 2007. <www.sciencedaily.com/releases/2007/04/070402102300.htm>.
Society for Experimental Biology. (2007, April 4). Fishing For Alternatives: Cultured Cell Lines And Organs Used To Help Study Effects Of Toxins. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2007/04/070402102300.htm
Society for Experimental Biology. "Fishing For Alternatives: Cultured Cell Lines And Organs Used To Help Study Effects Of Toxins." ScienceDaily. www.sciencedaily.com/releases/2007/04/070402102300.htm (accessed May 23, 2017).

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