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On The Defense: Conserved Features Of Plant Innate Immunity

Date:
June 18, 2007
Source:
Cold Spring Harbor Laboratory
Summary:
The innate immune response is the body's first line of defense against pathogen infection. Scientists report that three proteins work together in the MOS4-associated complex to execute innate immunity in the mustard weed, Arabidopsis.
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The innate immune response is the body's first line of defense against pathogen infection. In the June 15th issue of G&D, Dr. Xin Li (University of British Columbia) and colleagues report that three proteins work together in the MOS4-associated complex (MAC) to execute innate immunity in the mustard weed, Arabidopsis.

Dr. Li and colleagues study a plant autoimmune model in which a mutation in one immune receptor, SNC1, causes constitutive activation of the plant's immune response. Dr. Li's group found that 3 key downstream effectors of the SNC1 pathway -- MOS4, AtCDC5 and PRL1 -- are homologous to components of the human spliceosome-associated nineteen complex (NTC). The researchers speculate that the evolutionarily conserved NTC may also play a role in animal innate immunity.

"Our work is further evidence that the little plant Arabidopsis remains a very robust genetic tool for dissecting processes in multicellular eukaryotes, with relevance to the realm of human biology. To our knowledge, this is the first placement of the NTC into a known signaling pathway in any organism. We are continuing to find commonality between animal and plant innate immunity at the level of both receptors and signalling intermediates; the complex we describe, essential for plant innate immunity, may be another example of this."


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Cold Spring Harbor Laboratory. "On The Defense: Conserved Features Of Plant Innate Immunity." ScienceDaily. ScienceDaily, 18 June 2007. <www.sciencedaily.com/releases/2007/06/070617164058.htm>.
Cold Spring Harbor Laboratory. (2007, June 18). On The Defense: Conserved Features Of Plant Innate Immunity. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2007/06/070617164058.htm
Cold Spring Harbor Laboratory. "On The Defense: Conserved Features Of Plant Innate Immunity." ScienceDaily. www.sciencedaily.com/releases/2007/06/070617164058.htm (accessed May 23, 2017).

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