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Surprising New Role For Proteins In Sister Chromatid Cohesion

Date:
September 3, 2007
Source:
Cold Spring Harbor Laboratory
Summary:
Scientists reveal a surprising new role for tDNAs and RNA polymerase III-associated proteins in sister chromatid cohesion. Sister chromatid cohesion (the binding together of the two identical copies of each chromosome that are formed during replication) helps to ensure that chromosomes are accurately segregated during the anaphase of the cell cycle. Sister chromatid cohesion is mediated by a multi-subunit protein complex called cohesin. Inside the cell nucleus, cohesin localizes to centromeres (the point of attachment of sister chromatids) as well as heterochromatin (condensed and genetically inactive regions of DNA).
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In the September 1st issue of Genes & Development, Drs. Rudra Dubey and Marc Gartenberg (UMDNJ) reveal a surprising new role for tDNAs and RNA polymerase III-associated proteins in sister chromatid cohesion.

Sister chromatid cohesion (the binding together of the two identical copies of each chromosome that are formed during replication) helps to ensure that chromosomes are accurately segregated during the anaphase of the cell cycle. Sister chromatid cohesion is mediated by a multi-subunit protein complex called cohesin. Inside the cell nucleus, cohesin localizes to centromeres (the point of attachment of sister chromatids) as well as heterochromatin (condensed and genetically inactive regions of DNA).

To investigate cohesion, Drs. Dubey and Gartenberg used yeast cells, where cohesin is found at the transcriptionally inactive HMR mating-type locus. The researchers determined that a tRNA gene adjacent to HMR (which actually serves as a boundary element to delimit the transcriptionally silenced area of the chromosome) as well as components of the RNA pol III machinery are all required for establishment of silent chromatin cohesion at HMR.

"Recent studies have pointed to roles for tDNAs and RNA pol III transcription factors in the spatial organization of chromosomes. We are excited by the prospect that these same elements govern yet another layer of chromosome architecture through the establishment of sister chromatid cohesion," explains Dr. Gartenberg.


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Cite This Page:

Cold Spring Harbor Laboratory. "Surprising New Role For Proteins In Sister Chromatid Cohesion." ScienceDaily. ScienceDaily, 3 September 2007. <www.sciencedaily.com/releases/2007/08/070831171603.htm>.
Cold Spring Harbor Laboratory. (2007, September 3). Surprising New Role For Proteins In Sister Chromatid Cohesion. ScienceDaily. Retrieved June 24, 2024 from www.sciencedaily.com/releases/2007/08/070831171603.htm
Cold Spring Harbor Laboratory. "Surprising New Role For Proteins In Sister Chromatid Cohesion." ScienceDaily. www.sciencedaily.com/releases/2007/08/070831171603.htm (accessed June 24, 2024).

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