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Anti-cancer Drug Effective In Mouse Model Going To Clinical Trials

Date:
September 7, 2007
Source:
Journal of Clinical Investigation
Summary:
A new study demonstrates the anti-cancer effect of a new therapeutic (eIF4E-specific anti-sense oligonucleotides) in a mouse model of human tumors and has spawned clinical trials to test the ability of this therapeutic to treat human cancers.
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A new study by Jeremy Graff and colleagues from Eli Lilly and Company has demonstrated the anti-cancer effect of a new therapeutic in a mouse model of human tumors and has spawned clinical trials to test the ability of this therapeutic to treat human cancers.

As highlighted in the accompanying commentary by Celeste Simon and colleagues from the University of Pennsylvania, Philadelphia, if the therapeutic is as effective in clinical trials as it was in mice it will be useful for the treatment of a broad range of cancers.

The growth of many tumors is promoted by increased expression of the protein eIF4E, but no eIF4E-specific therapy has yet been developed.

In this study, the intravenous administration of eIF4E-specific antisense oligonucleotides (ASOs) to mice bearing human tumors substantially inhibited tumor growth. Importantly, although these ASOs also decreased eIF4E expression in normal tissues, the function of the normal tissues analyzed was not compromised.

The authors therefore suggest that tumor cells are more susceptible to decreased expression of eIF4E than normal cells, meaning that eIF4E-specific ASOs should not cause damage to normal tissues.

Article: Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity


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Materials provided by Journal of Clinical Investigation. Note: Content may be edited for style and length.


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Journal of Clinical Investigation. "Anti-cancer Drug Effective In Mouse Model Going To Clinical Trials." ScienceDaily. ScienceDaily, 7 September 2007. <www.sciencedaily.com/releases/2007/09/070904175429.htm>.
Journal of Clinical Investigation. (2007, September 7). Anti-cancer Drug Effective In Mouse Model Going To Clinical Trials. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2007/09/070904175429.htm
Journal of Clinical Investigation. "Anti-cancer Drug Effective In Mouse Model Going To Clinical Trials." ScienceDaily. www.sciencedaily.com/releases/2007/09/070904175429.htm (accessed May 23, 2017).

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