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New regulatory component in infectious bacterium discovered

Date:
September 2, 2014
Source:
University of Texas Health Science Center at Houston
Summary:
The discovery of a new regulatory component in an infectious bacterium could aid efforts to explain its ability to survive in the human body, report microbiologists. The scientists analyzed a bacterium called Enterococcus faecalis that is found in the gut of most adults. While in healthy people this bacterium is normally benign, certain strains can cause severe disease when they contaminate non-intestinal sites. It is a leading cause of health care-associated infection.
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The discovery of a new regulatory component in an infectious bacterium could aid efforts to explain its ability to survive in the human body, report microbiologists at The University of Texas Health Science Center at Houston (UTHealth) and University of Maryland, College Park, in the journal Science.

The scientists analyzed a bacterium called Enterococcus faecalis that is found in the gut of most adults. While in healthy people this bacterium is normally benign, certain strains can cause severe disease when they contaminate non-intestinal sites. It is a leading cause of health care-associated infection.

"We are trying to learn more about the interaction between E. faecalis and the host," said Danielle Garsin, Ph.D., co-senior author and associate professor in the Department of Microbiology and Molecular Genetics at the UTHealth Medical School. "Our goal is to understand how key genes and processes are regulated in this pathogen."

She added, "This information may lead to the development of novel therapeutics."

Garsin's research focused on a compound called ethanolamine (EA) that is potentially used by E. faecalis to survive in the human body. While the ability of E. faecalis to utilize EA was known, how the bug regulates the genes involved was not completely understood.

The scientists identified a novel regulatory component that was key to turning on the genes involved in EA metabolism under the right conditions. When researchers blocked the regulatory component, the molecular machinery was produced inappropriately.

"Not only does this regulatory component help explain how this particular process is controlled in E. faecalis, its discovery and elucidation increases our understanding of the variety and diversity of regulatory mechanisms in bacteria," Garsin said.


Story Source:

Materials provided by University of Texas Health Science Center at Houston. Note: Content may be edited for style and length.


Journal Reference:

  1. S. DebRoy, M. Gebbie, A. Ramesh, J. R. Goodson, M. R. Cruz, A. van Hoof, W. C. Winkler, D. A. Garsin. A riboswitch-containing sRNA controls gene expression by sequestration of a response regulator. Science, 2014; 345 (6199): 937 DOI: 10.1126/science.1255091

Cite This Page:

University of Texas Health Science Center at Houston. "New regulatory component in infectious bacterium discovered." ScienceDaily. ScienceDaily, 2 September 2014. <www.sciencedaily.com/releases/2014/09/140902205147.htm>.
University of Texas Health Science Center at Houston. (2014, September 2). New regulatory component in infectious bacterium discovered. ScienceDaily. Retrieved June 21, 2024 from www.sciencedaily.com/releases/2014/09/140902205147.htm
University of Texas Health Science Center at Houston. "New regulatory component in infectious bacterium discovered." ScienceDaily. www.sciencedaily.com/releases/2014/09/140902205147.htm (accessed June 21, 2024).

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