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Alternate drug therapy lowers antibodies, researchers find

Date:
December 23, 2014
Source:
University of Cincinnati Academic Health Center
Summary:
A novel pre-operative drug therapy reduces antibodies in kidney patients with greater success than with traditional methods, with the potential to increase the patients' candidacy for kidney transplantation and decrease the likelihood of organ rejection. These are the findings of a three-year clinical trial.
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Findings of a three-year clinical trial led by University of Cincinnati (UC) transplant researchers suggest that a novel pre-operative drug therapy reduces antibodies in kidney patients with greater success than with traditional methods, with the potential to increase the patients' candidacy for kidney transplantation and decrease the likelihood of organ rejection.

The study, titled "Prospective Iterative Trail of Proteasome Inhibitor-Based Desensitization," appears in the January 2015 edition of the American Journal of Transplantation.

Antibodies are something that all people have that are made by the immune system to protect against infections. Antibodies are Y-shaped proteins that in most instances are good because they help fight infection, but people can also make antibodies that work against other humans, which is often a major barrier to transplantation.

In an accompanying editorial, Klemens Budde, MD, head of the clinical transplant program at Charité -- Universitätsmedizin, Berlin, Germany, states, "The study provides first proof for a new desensitization strategy in immunized waitlisted patients."

"This study is important because it has the potential to change the way we approach kidney transplantation," says the study's principal investigator, E. Steve Woodle, MD, UC Health transplant surgeon and director of the division of transplantation at the UC College of Medicine, who adds: "This also may benefit 10 to 20 percent of heart and pancreas transplant candidates who often have such high levels of antibodies that transplantation is nearly impossible."

Since 2008, the UC research team has been on forefront of developing therapies that target plasma cells -- the cells that make antibodies. These new therapies have used bortezomib, a proteasome inhibitor that is already approved by the FDA for treatment of multiple myeloma. The traditional method for reducing antibody levels, Woodle says, uses a blood product termed intravenous immuneglobulin (IVIG).

Woodle adds that the data from studies with IVIG is inconsistent with most patients being unresponsive. In this first-of-its-kind trial, however, 50 kidney transplant candidates with high antibody levels were treated with the new regimen.

"The rejection rates were low and the chances of the patient developing a new antibody against their kidney were very low. In addition, in some patients, antibodies remained suppressed for several months -- something that has not previously been described with other approaches,'' says Woodle.

Four new regimens -- described by Woodle as "second-generation plasma cell-targeted therapies" -- will be evaluated by the UC Transplant Clinical Research team in 2015. These future studies will also be complemented by mechanistic studies in collaboration with James Driscoll, MD, PhD, assistant professor in UC's division of hematology oncology and a member of the UC Cancer Institute.


Story Source:

Materials provided by University of Cincinnati Academic Health Center. Note: Content may be edited for style and length.


Journal Reference:

  1. E. S. Woodle, A. R. Shields, N. S. Ejaz, B. Sadaka, A. Girnita, R. C. Walsh, R. R. Alloway, P. Brailey, M. A. Cardi, B. G. Abu Jawdeh, P. Roy-Chaudhury, A. Govil, G. Mogilishetty. Prospective Iterative Trial of Proteasome Inhibitor-Based Desensitization. American Journal of Transplantation, 2015; 15 (1): 101 DOI: 10.1111/ajt.13050

Cite This Page:

University of Cincinnati Academic Health Center. "Alternate drug therapy lowers antibodies, researchers find." ScienceDaily. ScienceDaily, 23 December 2014. <www.sciencedaily.com/releases/2014/12/141223161125.htm>.
University of Cincinnati Academic Health Center. (2014, December 23). Alternate drug therapy lowers antibodies, researchers find. ScienceDaily. Retrieved April 12, 2024 from www.sciencedaily.com/releases/2014/12/141223161125.htm
University of Cincinnati Academic Health Center. "Alternate drug therapy lowers antibodies, researchers find." ScienceDaily. www.sciencedaily.com/releases/2014/12/141223161125.htm (accessed April 12, 2024).

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