Science News
from research organizations

Microbial metabolite of linoleic acid ameliorates intestinal inflammation

Date:
February 18, 2015
Source:
Hiroshima University
Summary:
10-hydroxy-cis-12-octadecenoic acid (HYA), a gut microbial metabolite of linoleic acid, has a suppressive effect on intestinal inflammation, researchers have discovered. HYA is expected to be practically applied as a functional food.
Share:
FULL STORY

A Japanese research group has demonstrated that 10-hydroxy-cis-12-octadecenoic acid (HYA), a gut microbial metabolite of linoleic acid, has a suppressive effect on intestinal inflammation. HYA is expected to be practically applied as a functional food.

Inflammatory bowel diseases (IBDs), including Crohn disease and ulcerative colitis, are hard to completely cure. Globally, IBDs affect more than 4 million people today. However, Professor Soichi Tanabe (Graduate School of Biosphere Science, Hiroshima University) and his collaborators have demonstrated that 10-hydroxy-cis-12-octadecenoic acid (HYA), a gut microbial metabolite of linoleic acid, has a suppressive effect on intestinal inflammation. HYA is expected to be practically applied as a functional food. The results of this group's research were published in The Journal of Biological Chemistry as "A gut microbial metabolite of linoleic acid, 10-hydroxy-cis-12-octadecenoic acid, ameliorates intestinal epithelial barrier impairment partially via GPR40-MEK-ERK pathway" DOI: 10.1074/jbc.M114.610733.

IBD patients characteristically demonstrate increased expression of tumor necrosis factor receptor-2 and an upregulated inflammatory NF-κB pathway.

Professor Tanabe and his colleagues demonstrated that HYA binds to a G protein-coupled receptor (GPR40) and ameliorates intestinal epithelial barrier impairment in an intestinal epithelial cell line, Caco-2 cells; oral administration of HYA also alleviates colitis in mice.

The physiological activity of gut microbial metabolites has recently attracted considerable attention. HYA may be useful in the treatment of tight junction-related disorders, such as IBD.


Story Source:

Materials provided by Hiroshima University. Note: Content may be edited for style and length.


Journal Reference:

  1. Junki Miyamoto, Taichi Mizukure, Si-Bum Park, Shigenobu Kishino, Ikuo Kimura, Kanako Hirano, Paolo Bergamo, Mauro Rossi, Takuya Suzuki, Makoto Arita, Jun Ogawa, Soichi Tanabe. A Gut Microbial Metabolite of Linoleic Acid, 10-Hydroxy-cis-12-octadecenoic Acid, Ameliorates Intestinal Epithelial Barrier Impairment Partially via GPR40-MEK-ERK Pathway. Journal of Biological Chemistry, 2015; 290 (5): 2902 DOI: 10.1074/jbc.M114.610733

Cite This Page:

Hiroshima University. "Microbial metabolite of linoleic acid ameliorates intestinal inflammation." ScienceDaily. ScienceDaily, 18 February 2015. <www.sciencedaily.com/releases/2015/02/150218073113.htm>.
Hiroshima University. (2015, February 18). Microbial metabolite of linoleic acid ameliorates intestinal inflammation. ScienceDaily. Retrieved May 24, 2017 from www.sciencedaily.com/releases/2015/02/150218073113.htm
Hiroshima University. "Microbial metabolite of linoleic acid ameliorates intestinal inflammation." ScienceDaily. www.sciencedaily.com/releases/2015/02/150218073113.htm (accessed May 24, 2017).

RELATED STORIES