While synapses contain hundreds to thousands of synaptic vesicles, when a specific signal is received by the neuron, only a fraction of synaptic vesicles that exist in what is called the readily releasable pool are discharged from one neuron to another. Previous studies have demonstrated that within the readily releasable pool, synaptic vesicles have different specific kinetic properties of release that impact the type and bandwidth of information that can be relayed in response to stimulation. What was not known was the cellular mechanisms that regulate the release of synaptic vesicles from the readily releasable pool to support the early stages of auditory processing.
In their February publication in the Journal of Neuroscience, the authors of the manuscript report that a dominant factor regulating the properties of synaptic vesicle release supporting the early stages of auditory processing is the distance between the synaptic vesicles and voltage gated calcium channels within a synapse. The authors characterized the readily releasable pool of synaptic vesicles at the calyx of Held, a critical component of auditory processing, employing several different techniques that allowed them to investigate the pre-synaptic mechanisms of informational transmittal. This study identifies the critical mechanism is the regulation of Ca2+ influx through voltage gated calcium channels and release of neurotransmitters by synaptic vesicles. These findings are important for understanding the mechanisms of synaptic transmission, specifically for neuronal circuits that rely on fast, continuous synaptic transmission.
"It is becoming apparent that the underlying cause of most neuropsychiatric or neurodegenerative diseases is a dysfunction of the synapse," explained Dr. Young. "Identifying what factors are involved in proper synaptic transmission and neural circuit function have tremendous potential as therapies for neurological disorders or brain injury."
According to Dr. Young, the future goals of this project are to uncover molecular mechanisms that allow synapses to sustain synaptic transmission over a wide range of activity levels to allow for proper information processing by the neuronal circuit in which they are embedded.
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