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Inflammation in mouth, joints in rheumatoid arthritis

Date:
March 12, 2015
Source:
International & American Associations for Dental Research
Summary:
Periodontitis shares pathogenic mechanisms with rheumatoid arthritis (RA) and may trigger its onset, scientists say. In a new study, researchers performed joint and dental examinations, determined Porphyromonas gingivalis (P. gingivalis) antibodies, and examined inflammatory microenvironments in early and chronic RA patients.
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At the 93rd General Session and Exhibition of the International Association for Dental Research, researcher Sheila Arvikar, Massachusetts General Hospital, Boston, USA, will present a study titled "Inflammation in the Mouth and Joints in Rheumatoid Arthritis." The IADR General Session is being held in conjunction with the 44th Annual Meeting of the American Association for Dental Research and the 39th Annual Meeting of the Canadian Association for Dental Research.

Periodontitis shares pathogenic mechanisms with rheumatoid arthritis (RA) and may trigger its onset. In this study, researchers performed joint and dental examinations, determined Porphyromonas gingivalis (P. gingivalis) antibodies, and examined inflammatory microenvironments in early and chronic RA patients.

Twenty-three RA patients, (15 new-onset disease, eight chronic) and 20 age/gender-matched healthy subjects (HS) without periodontitis/RA were enrolled in this study. Serum P. gingivalis IgG antibodies were measured by ELISA. Twenty inflammatory mediators were measured in serum, saliva, gingival crevicular fluid (GCF), and joint fluid by Luminex.

The 23 patients (87% female) received routine dental care, except for one; none currently smoked. Of the 23 RA patients, 10 had gingivitis and nine had periodontitis. RA patients exhibited increased pocket depth, clinical attachment loss, bleeding on probing and GCF volume compared with HS. Six of 23 patients had P. gingivalis antibodies, and all six had periodontitis.

RA patients showed a marked inflammatory profile in all microenvironments, including oral, despite routine dental care. P. gingivalis antibodies can be considered as biomarkers for rheumatologists in identifying those who may benefit from periodontal treatment.


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International & American Associations for Dental Research. "Inflammation in mouth, joints in rheumatoid arthritis." ScienceDaily. ScienceDaily, 12 March 2015. <www.sciencedaily.com/releases/2015/03/150312123526.htm>.
International & American Associations for Dental Research. (2015, March 12). Inflammation in mouth, joints in rheumatoid arthritis. ScienceDaily. Retrieved March 27, 2017 from www.sciencedaily.com/releases/2015/03/150312123526.htm
International & American Associations for Dental Research. "Inflammation in mouth, joints in rheumatoid arthritis." ScienceDaily. www.sciencedaily.com/releases/2015/03/150312123526.htm (accessed March 27, 2017).