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C. difficile rates highest in Northeast region of U.S., spring season

Date:
April 28, 2015
Source:
Elsevier Health Sciences
Summary:
Rates of infection with the deadly superbug Clostridium difficile were highest in the Northeast region of the country and in the spring season over the last 10 years, according to a new study.
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Rates of infection with the deadly superbug Clostridium difficile were highest in the Northeast region of the country and in the spring season over the last 10 years, according to a study published in the May issue of the American Journal of Infection Control, the official publication of the Association for Professionals in Infection Control and Epidemiology (APIC).

Researchers from the University of Texas retrospectively analyzed 2.3 million cases of C. difficile infection (CDI) from 2001-2010 and found the highest incidence in the Northeast (8.0 CDI discharges/1000 total discharges), followed by the Midwest (6.4/1000), South (5.0/1000), and the West (4.8/1000).

Seasonally, spring had the most cases (6.2 CDI discharges/1000 total discharges), followed by winter (5.9/1000), summer (5.9/1000) and fall (5.6/1000). Adults and older adults followed overall trends, whereas pediatric CDI was highest in winter.

CDI mortality was highest in the Midwest (7.3 percent) and among older adults (9.0 percent).

"The peak incidence in the spring could be attributed to increased utilization of antibiotics in winter months," the authors state. "Prior studies have found a 1 to 2 month lag time between antibiotic exposure and the development of CDI."

C. difficile causes inflammation of the colon and life-threatening diarrhea. According to the CDC, C. difficile has become the most common microbial cause of healthcare-associated infections in U.S. hospitals and costs up to $4.8 billion each year in excess healthcare costs for acute care facilities alone. The CDC estimates that C. difficile caused almost half a million infections in 2011 and that 29,000 U.S. patients died within 30 days of their initial diagnosis.


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Materials provided by Elsevier Health Sciences. Note: Content may be edited for style and length.


Journal Reference:

  1. Jacqueline R. Argamany, Samuel L. Aitken, Grace C. Lee, Natalie K. Boyd, and Kelly R. Reveles. Regional and seasonal variation in Clostridium difficile infections among hospitalized patients in the United States, 2001-2010. American Journal of Infection Control, Volume 43, Issue 5 (May 2015)

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Elsevier Health Sciences. "C. difficile rates highest in Northeast region of U.S., spring season." ScienceDaily. ScienceDaily, 28 April 2015. <www.sciencedaily.com/releases/2015/04/150428171412.htm>.
Elsevier Health Sciences. (2015, April 28). C. difficile rates highest in Northeast region of U.S., spring season. ScienceDaily. Retrieved May 26, 2017 from www.sciencedaily.com/releases/2015/04/150428171412.htm
Elsevier Health Sciences. "C. difficile rates highest in Northeast region of U.S., spring season." ScienceDaily. www.sciencedaily.com/releases/2015/04/150428171412.htm (accessed May 26, 2017).

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