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Drug extends survival of patients with metastatic colorectal cancer

Date:
May 13, 2015
Source:
Dana-Farber Cancer Institute
Summary:
A drug developed 50 years ago and abandoned because it was considered to be too toxic has gained a second life in an international clinical trial. Research shows the drug and a potentiating agent lengthened the lives of patients with metastatic colorectal cancer, all of whom had exhausted available standard treatments.
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A drug developed 50 years ago and abandoned because it was considered to be too toxic has gained a second life in an international clinical trial. Research led by scientists at Dana-Farber Cancer Institute showed the drug and a potentiating agent lengthened the lives of patients with metastatic colorectal cancer, all of whom had exhausted available standard treatments.

In a paper published online by the New England Journal of Medicine, investigators at Dana-Farber and research centers around the world found that the drug combination -- given as a single pill known as TAS-102 -- not only extended patients' overall survival, but also delayed the advance of the disease and did so with very few side effects.

According to the study authors, the results are especially impressive because half of the patients had just finished treatment with the standard class of chemotherapy agents -- fluoropyrimidines (e.g. 5-fluorouracil [5-FU] or capecitabine [Xeloda]) but had failed to benefit from them. The fact that TAS-102 temporarily halted the disease in many of these patients suggests that it operates through a different biochemical pathway than 5-FU, and therefore may serve as an alternative to standard therapy.

"Colorectal cancer is the second most common cause of cancer deaths [after lung cancer] in the United States and is an enormous health problem around the world," said the study's lead author, Robert J. Mayer, MD, faculty vice president for academic affairs, medical oncologist and colorectal cancer researcher at Dana-Farber. "To have a well-tolerated, effective new drug in a cancer that is so prevalent is good news for patients."

The trial, a phase 3 study involving major cancer research institutions in Europe, the United States, Australia and Japan, enrolled 800 patients with metastatic colorectal cancer that was progressing despite previous treatment. Participants were randomly assigned to receive TAS-102 or a placebo pill.

The median survival period for patients receiving TAS-102 was 7.1 months, compared to 5.3 months for patients taking a placebo, investigators reported. The median time before the disease worsened was 5.7 months for the TAS-102 group and 4.0 months for the placebo group.

Although these gains may seem small, the fact that they occurred in patients whose cancer no longer responded to other therapies suggests TAS-102 holds real promise as a treatment for the disease, the study authors said.

The cancer cell-killing component of TAS-102, a drug known as trifluridine, was developed in the late 1950s, at about the same period as 5-FU. At the time, 5-FU was thought to work by being incorporated into cancer cells' DNA and preventing the cells from metabolizing nutrients. Later, it was learned that the drug actually works by blocking an enzyme (thymidylate synthase) that the cells need for survival.

Trifluridine, by contrast, does integrate into cancer cell DNA, but proved to be too toxic to patients when given in doses necessary to kill the cancer cells. About 15 years ago, the Japanese company Taiho Pharmaceutical began testing trifluridine in combination with tipiracil hydrochloride, an agent that blocks the metabolism of trifluridine. The combination allowed trifluridine to exert its beneficial effect without reaching toxic levels, thereby making it a potentially useful form of anticancer therapy.

Initial clinical studies in Japan in patients with colorectal cancer showed promising results, leading to small trials in the U.S. led by investigators at Dana-Farber and other research centers. Those trials showed the drug to be well tolerated in American patients, spurring the launching of the phase 3 trial.

"When we first saw the data from the trial, they were unequivocally positive," Mayer said. "The benefits of the drug were observed in patients regardless of age, ethnicity, sex, or the molecular make-up of their tumor."

The next step will be to test TAS-102 in combination with other drugs that are customarily used in conjunction with 5-FU, and compare results, Mayer said.


Story Source:

Materials provided by Dana-Farber Cancer Institute. Note: Content may be edited for style and length.


Journal Reference:

  1. Robert J. Mayer, Eric Van Cutsem, Alfredo Falcone, Takayuki Yoshino, Rocio Garcia-Carbonero, Nobuyuki Mizunuma, Kentaro Yamazaki, Yasuhiro Shimada, Josep Tabernero, Yoshito Komatsu, Alberto Sobrero, Eveline Boucher, Marc Peeters, Ben Tran, Heinz-Josef Lenz, Alberto Zaniboni, Howard Hochster, James M. Cleary, Hans Prenen, Fabio Benedetti, Hirokazu Mizuguchi, Lukas Makris, Masanobu Ito, Atsushi Ohtsu. Randomized Trial of TAS-102 for Refractory Metastatic Colorectal Cancer. New England Journal of Medicine, 2015; 372 (20): 1909 DOI: 10.1056/NEJMoa1414325

Cite This Page:

Dana-Farber Cancer Institute. "Drug extends survival of patients with metastatic colorectal cancer." ScienceDaily. ScienceDaily, 13 May 2015. <www.sciencedaily.com/releases/2015/05/150513211132.htm>.
Dana-Farber Cancer Institute. (2015, May 13). Drug extends survival of patients with metastatic colorectal cancer. ScienceDaily. Retrieved May 24, 2017 from www.sciencedaily.com/releases/2015/05/150513211132.htm
Dana-Farber Cancer Institute. "Drug extends survival of patients with metastatic colorectal cancer." ScienceDaily. www.sciencedaily.com/releases/2015/05/150513211132.htm (accessed May 24, 2017).

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