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New approach to treating B-cell acute lymphoblastic leukemia shows promise

Novel compound stops tumor cell growth and lengthens survival in animal studies

Date:
July 13, 2015
Source:
Dana-Farber Cancer Institute
Summary:
A new compound that locks a disease-related protein into an inactive position stifled the growth of an aggressive form of leukemia in laboratory and animal tests, researchers report.
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A new compound that locks a disease-related protein into an inactive position stifled the growth of an aggressive form of leukemia in laboratory and animal tests, researchers at Dana-Farber Cancer Institute and other institutions report. When the compound was combined with a steroid, the leukemia was reduced even further and the animals lived longer than they did when treated with the compound alone.

The results, published online July 13 by the journal Cancer Cell, demonstrate that the technique -- in which a drug compound shuts down the protein by snapping it closed, preventing it from functioning -- can be especially effective in some cancers. "Our results were achieved in an aggressive type of B-cell acute lymphoblastic leukemia [B-ALL], the most common cancer in children and a highly fatal disease in adults," said David Weinstock, MD, of Dana-Farber, the co-senior author of the study with Christoph Gaul, PhD, of Novartis Institute for Biomedical Research. "But because the same protein is found in an abnormal form in other cancers, this approach holds promise for treating them as well."

The study involved a variety of B-ALL in which the cancer cells carry a rearrangement of the gene CRLF2. (Such rearrangements occur when DNA damage causes certain genes to be out of their proper order in a chromosome.) While most children with B-ALL can be successfully treated, those with this genetic variant often do not fare as well.

One of the most inviting targets on B-ALL cells with CRLF2 rearrangements is a signaling protein called JAK2, which the cells rely on to grow and survive. Drugs that block JAK2 have received Food and Drug Administration approval for treating diseases such as myeloproliferative disorders (which affect blood cell growth in the bone marrow) and rheumatoid arthritis, but they have not been successful in cancer. "While these drugs can reduce the symptoms associated with certain cancers, they don't alter the natural course of the disease," Weinstock said.

Researchers have shown that such "type I" JAK2 inhibitors fail in cancer because the tumor cells manage to re-route the chemical signals that usually pass through JAK2. This allows the cells to resume their hectic growth and division.

In the new study, Weinstock and his colleagues tested a type II JAK2 inhibitor, which uses a different strategy against the errant protein. Made by Novartis, the inhibitor, called CHZ868, binds JAK2 into a tightly clenched position that prevents it from functioning.

Weinstock's team tested the agent in laboratory samples of B-ALL with CRLF2 rearrangement, in mice with the disease, and in mice implanted with human B-ALL tissue. "In each case, we saw good activity: leukemia cells died, JAK2 signaling was suspended, and survival rates increased," Weinstock said. "When we combined CHZ868 with the steroid dexamethasone, the killing of leukemia cells was much more extensive and the animals lived longer than they did with CHZ868 alone."

Especially encouraging was the lack of bone marrow problems in the treated mice, a possible side effect of JAK2 inhibitors, Weinstock added.

"JAK2 abnormalities are found in some cases of triple-negative breast cancer and Hodgkin lymphoma," he continued. "The success of CHZ868 in B-ALL suggests that it, or a compound that works by a similar mechanism, may also be effective in these cancers."


Story Source:

Materials provided by Dana-Farber Cancer Institute. Note: Content may be edited for style and length.


Journal Reference:

  1. Shuo-Chieh Wu, Loretta S. Li, Nadja Kopp, Joan Montero, Bjoern Chapuy, Akinori Yoda, Amanda L. Christie, Huiyun Liu, Alexandra Christodoulou, Diederik van Bodegom, Jordy van der Zwet, Jacob V. Layer, Trevor Tivey, Andrew A. Lane, Jeremy A. Ryan, Samuel Y. Ng, Daniel J. DeAngelo, Richard M. Stone, David Steensma, Martha Wadleigh, Marian Harris, Emeline Mandon, Nicolas Ebel, Rita Andraos, Vincent Romanet, Arno Dölemeyer, Dario Sterker, Michael Zender, Scott J. Rodig, Masato Murakami, Francesco Hofmann, Frank Kuo, Michael J. Eck, Lewis B. Silverman, Stephen E. Sallan, Anthony Letai, Fabienne Baffert, Eric Vangrevelinghe, Thomas Radimerski, Christoph Gaul, David M. Weinstock. Activity of the Type II JAK2 Inhibitor CHZ868 in B Cell Acute Lymphoblastic Leukemia. Cancer Cell, 2015; 28 (1): 29 DOI: 10.1016/j.ccell.2015.06.005

Cite This Page:

Dana-Farber Cancer Institute. "New approach to treating B-cell acute lymphoblastic leukemia shows promise: Novel compound stops tumor cell growth and lengthens survival in animal studies." ScienceDaily. ScienceDaily, 13 July 2015. <www.sciencedaily.com/releases/2015/07/150713131338.htm>.
Dana-Farber Cancer Institute. (2015, July 13). New approach to treating B-cell acute lymphoblastic leukemia shows promise: Novel compound stops tumor cell growth and lengthens survival in animal studies. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2015/07/150713131338.htm
Dana-Farber Cancer Institute. "New approach to treating B-cell acute lymphoblastic leukemia shows promise: Novel compound stops tumor cell growth and lengthens survival in animal studies." ScienceDaily. www.sciencedaily.com/releases/2015/07/150713131338.htm (accessed May 23, 2017).

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