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Probiotics show no impact preventing gastrointestinal colonization with drug-resistant bugs in ICU

ICU patients receive no benefit or harm from probiotic use

Date:
August 27, 2015
Source:
Society for Healthcare Epidemiology of America
Summary:
Probiotics show no benefit for preventing or eliminating gastrointestinal colonization with drug-resistant organisms in patients in the intensive care unit compared to standard care, according to new research.
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Probiotics show no benefit for preventing or eliminating gastrointestinal colonization with drug-resistant organisms in patients in the intensive care unit compared to standard care, according to new research published online today in Infection Control & Hospital Epidemiology, the journal of the Society for Healthcare Epidemiology of America.

"Our research suggests that probiotics do not help prevent gastrointestinal colonization with multidrug-resistant organisms in critically ill patients," said Jennie H. Kwon, DO, lead author of the study.

This prospective, randomized controlled pilot study, conducted over a 21-month period, followed 70 patients admitted to intensive care units at Barnes-Jewish Hospital in St. Louis. The research team from the Washington University School of Medicine in St. Louis sought to determine if the probiotic Lactobacillus rhamnosus GG could prevent gastrointestinal colonization of multi-drug resistant organisms (MDROs), such as Clostridium difficile, vancomycin-resistant Enterococcus (VRE), and Pseudomonas aeruginosa. Each patient was followed for 14 days or until they left the unit

There was no significant difference in overall acquisition of any MRDOs between the two groups. A safety assessment of the use of probiotics in this patient population found that there were no significant differences in mortality rates between the two groups and no adverse events related to use of the probiotic.

Limitations of the study included the small sample size of patients, duration of follow-up, and inclusion of a single type of dose of probiotic.

"Further research is needed on this emerging intervention to evaluate the effectiveness in preventing intestinal colonization of drug-resistant organisms," said Dr. Kwon. Researchers also noted that their study was confined to lower intestinal bacteria and did not assess possible impact on bacteria in the stomach or upper airways.


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Materials provided by Society for Healthcare Epidemiology of America. Note: Content may be edited for style and length.


Journal Reference:

  1. Jennie H. Kwon, Kerry M. Bommarito, Kimberly A. Reske, Sondra M. Seiler, Tiffany Hink, Hilary M. Babcock, Marin H. Kollef, Victoria J. Fraser, Carey-Ann D. Burnham, Erik R. Dubberke. Randomized Controlled Trial to Determine the Impact of Probiotic Administration on Colonization With Multidrug-Resistant Organisms in Critically Ill Patients. Infection Control & Hospital Epidemiology, 2015

Cite This Page:

Society for Healthcare Epidemiology of America. "Probiotics show no impact preventing gastrointestinal colonization with drug-resistant bugs in ICU: ICU patients receive no benefit or harm from probiotic use." ScienceDaily. ScienceDaily, 27 August 2015. <www.sciencedaily.com/releases/2015/08/150827111641.htm>.
Society for Healthcare Epidemiology of America. (2015, August 27). Probiotics show no impact preventing gastrointestinal colonization with drug-resistant bugs in ICU: ICU patients receive no benefit or harm from probiotic use. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2015/08/150827111641.htm
Society for Healthcare Epidemiology of America. "Probiotics show no impact preventing gastrointestinal colonization with drug-resistant bugs in ICU: ICU patients receive no benefit or harm from probiotic use." ScienceDaily. www.sciencedaily.com/releases/2015/08/150827111641.htm (accessed May 23, 2017).

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