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New smart robot accelerates cancer treatment research

Date:
September 22, 2015
Source:
Uppsala Universitet
Summary:
A new smart research robot accelerates research on cancer treatments by finding optimal treatment combinations, experts report. For patients with the same cancer type returning multiple times, sometimes the cancer cells develop resistance against the pharmacotherapy used. The new robot systems may also become important in the efforts to find new drug compounds that make these resistant cells sensitive again, they add.
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A new smart research robot accelerates research on cancer treatments. The new robot system finds optimal treatment combinations. Scientific Reports (Nature Publishing Group) is publishing an article about the robot, authored by Dr Mats Gustafsson, Professor of Medical Bioinformatics at Uppsala University.

Today complex diseases like cancer is medically almost exclusively treated by combining several different drugs. These combinations are typically composed from drugs that show effect on their own, but do not necessarily constitute the best possible combinations. The new robot system finds optimal treatment combinations and was developed by a research group led by Dr Mats Gustafsson, Professor of Medical Bioinformatics at Uppsala University.

'We have built a robot system that plans and conducts experiments with many substances, and draws its own conclusions from the results. The idea is to gradually refine combinations of substances so that they kill cancer cells without harming healthy cells', says Dr Claes Andersson, also a leading scientist in the project.

Instead of just combining a couple of substances at a time, the new lab robot has the ability to handle on the order of a dozen drugs simultaneously. The aim for the future is to be able to handle many more, preferably hundreds.

'We are now one among the few laboratories in the world with this type of lab robot. However, so far researchers have only used the systems to look for combinations that kills the cancer cells, not taking the side effects into account', says Mats Gustafsson.

The next step in the development is to make the robot system more automated and smarter. The current version still involves a few manual steps that could be automated. The scientists also want to build more prior knowledge into the guiding algorithm of the robot, for example, prior knowledge about drug targets and disease pathways.

For patients with the same cancer type returning multiple times, sometimes the cancer cells develop resistance against the pharmacotherapy used. The new robot systems may also become important in the efforts to find new drug compounds that make these resistant cells sensitive again.

An article about the robot system was presented in Scientific Reports, and is part of a doctoral thesis on drug combinations, recently defended by Dr Muhammad Kashif.


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Materials provided by Uppsala Universitet. Note: Content may be edited for style and length.


Journal Reference:

  1. M. Kashif, C. Andersson, S. Hassan, H. Karlsson, W. Senkowski, M. Fryknäs, P. Nygren, R. Larsson, M.G. Gustafsson. In vitro discovery of promising anti-cancer drug combinations using iterative maximisation of a therapeutic index. Scientific Reports, 2015; 5: 14118 DOI: 10.1038/srep14118

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Uppsala Universitet. "New smart robot accelerates cancer treatment research." ScienceDaily. ScienceDaily, 22 September 2015. <www.sciencedaily.com/releases/2015/09/150922104456.htm>.
Uppsala Universitet. (2015, September 22). New smart robot accelerates cancer treatment research. ScienceDaily. Retrieved May 8, 2017 from www.sciencedaily.com/releases/2015/09/150922104456.htm
Uppsala Universitet. "New smart robot accelerates cancer treatment research." ScienceDaily. www.sciencedaily.com/releases/2015/09/150922104456.htm (accessed May 8, 2017).