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Botox may prevent irregular heartbeat after bypass surgery

October 20, 2015
American Heart Association
Botox injections into fat surrounding the heart reduced the chances of developing an irregular heart rhythm -- the most common complication of bypass surgery -- say scientists.

Botox -- known for reducing facial wrinkles -- may also prevent irregular heart rhythms when injected into fat surrounding the heart after bypass surgery, according to research in the American Heart Association journal Circulation: Arrhythmia and Electrophysiology.

Botulinum toxin, commonly known as Botox, is produced by Clostridium botulinum bacteria. When a small amount of Botox is injected into a muscle, it blocks nerve signals that tell muscles to contract.

Atrial fibrillation (also called AFib or AF) is a quivering or irregular heartbeat (arrhythmia) that can lead to blood clots, stroke, heart failure and other heart-related complications.

"About a third of all patients undergoing bypass surgery will develop atrial fibrillation, putting them at higher risk for cardiovascular complications," said Jonathan S. Steinberg, M.D., senior study author and Adjunct Professor of Medicine at the University of Rochester and Director of the Arrhythmia Institute in the Valley Health System in Ridgewood, New Jersey. "Atrial fibrillation is also always associated with lengthened hospitalization and that means increased healthcare costs."

In two Russian hospitals, researchers randomly assigned 60 patients to receive Botox or saline injections. The injections were made in the four major fat pads surrounding the heart. To avoid bias, neither patients nor doctors knew whether the injections contained Botox or saline.

Researchers found that:

  • In the 30 days following surgery, those who received Botox injections during heart bypass surgery had a 7 percent chance of developing AF, compared to 30 percent chance in patients who received saline.
  • One year after surgery, none of the patients who received Botox had AF, compared to 27 percent of the patients who received saline.
  • No complications from the Botox injections were reported. But complications from the bypass surgery were similar in both groups, including time in intensive care and on a breathing machine, and infection rate.

The results must be replicated in larger studies before Botox injections are routinely used to prevent AF after bypass surgery, researchers said. If confirmed in heart bypass patients, Botox injections could also help prevent AF in people undergoing valve repair or replacement. About half of those patients will develop AF after surgery.

"This first-in-man study has opened a whole new line of thinking and research," Steinberg said. "In the near future, botox injections may become the standard of care for heart bypass and valve patients, but we're not quite there yet."

Story Source:

Materials provided by American Heart Association. Note: Content may be edited for style and length.

Journal Reference:

  1. Evgeny Pokushalov, Boris Kozlov, Alexander Romanov, Artem Strelnikov, Sevda Bayramova, David Sergeevichev, Alexander Bogachev-Prokophiev, Sergey Zheleznev, Vladimir Shipulin, Vladimir V. Lomivorotov, Alexander Karaskov, Sunny S. Po, and Jonathan S. Steinberg. Long-Term Suppression of Atrial Fibrillation by Botulinum Toxin Injection into Epicardial Fat Pads in Patients Undergoing Cardiac Surgery: One Year Follow Up of a Randomized Pilot Study. Circulation: Arrhythmia and Electrophysiology, October 2015 DOI: 10.1161/CIRCEP.115.003199

Cite This Page:

American Heart Association. "Botox may prevent irregular heartbeat after bypass surgery." ScienceDaily. ScienceDaily, 20 October 2015. <>.
American Heart Association. (2015, October 20). Botox may prevent irregular heartbeat after bypass surgery. ScienceDaily. Retrieved February 28, 2024 from
American Heart Association. "Botox may prevent irregular heartbeat after bypass surgery." ScienceDaily. (accessed February 28, 2024).

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