Science News
from research organizations

New genetic clues to age-related macular degeneration

Date:
December 21, 2015
Source:
University of Southampton
Summary:
An international study has significantly expanded the number of genetic factors known to play a role in age-related macular degeneration (AMD), a leading cause of vision loss among people age 50 and older. Researchers hope the findings may help improve the understanding of the biological processes that lead to AMD and identify new therapeutic targets for potential drug development.
Share:
FULL STORY

An international study, involving researchers at the University of Southampton and Southampton General Hospital, has significantly expanded the number of genetic factors known to play a role in age-related macular degeneration (AMD), a leading cause of vision loss among people age 50 and older.

Professor Andrew Lotery, who led the Southampton contribution, hopes the findings may help improve the understanding of the biological processes that lead to AMD and identify new therapeutic targets for potential drug development.

He said: "This is a landmark study which has identified 34 genes which when faulty increase your risk of developing this devastating disease. Identifying these genes is the key to understanding what causes AMD. As a result this could open new doors to finding more efficient ways of treating this very common disease.

"AMD currently affects more than 600,000 people in the UK and 50 million individuals worldwide. This figure is expected to quadruple by 2020 and be almost 300 million by 2040. We urgently need new treatments to stop people spending their twilight years blind. Finding these genes means we can now investigate what the gene variations are doing and how they interact with each other to see how AMD is formed. This study is an amazing achievement and shows the power of having scientists all over the world working together."

AMD is a progressive disease that causes the death of the retinal photoreceptors, the light-sensitive cells at the back of the eye. The most severe damage occurs in the macula, a small area of the retina that is needed for sharp, central vision necessary for reading, driving and other daily tasks.

There are two different types of AMD -- 'wet' and 'dry'. Dry AMD is the more common, however there are no approved treatments yet, whereas the growth of wet AMD can be stopped. However, the therapies do not cure the condition, nor do they work for everyone.

AMD is caused by a combination of genetic, environmental and lifestyle risk factors. For example, smoking increases the risk of AMD, while eating leafy greens and fish, such as salmon, halibut, and tuna, may reduce the risk. Up to this point, researchers had identified 21 regions of the genome-called loci-that influence the risk of AMD. The new research, funded by the National Eye Institute (NEI), part of the National Institutes of Health and published in Nature Genetics, brings the number up to 34 loci.

The International AMD Genomics Consortium, which includes 26 centres worldwide, and of which Southampton is one, collected and analysed the genetic data from 43,566 people of predominantly European ancestry to systematically identify common and rare variations in genetic coding associated with AMD.

Common variations generally have an indirect association with a disease. Rare variations, by contrast, are more likely to alter protein expression or function and therefore have a direct or causal association with a disease. Rare variations were defined as those found in less than one per cent of the study population.

The study included about 23,000 participants with AMD and 20,000 without it, of which the Southampton team contributed more 1000 samples. The researchers analysed DNA samples from both groups, surveying most of the genome, but also focusing on distinct loci already known or suspected to be associated with AMD. They compared the participants' DNA to a reference dataset called the 1000 Genomes Project, yielding more than 12 million genetic variants of potential interest. Finally, they went back to the participants' DNA samples, looking at all 12 million variants, to see if any were found more or less often in people with AMD than those without it.

"The investigation is akin to looking at a Google map of the United States and attempting to pinpoint several leaders and satellite operations in a crime syndicate," said a co-leader of the study, Anand Swaroop, Ph.D., chief of NEI's Neurobiology-Neurodegeneration and Repair Laboratory. "It's possible to find the key players by zooming in and seeing specific regions in rich detail, but first you have to know where to look. Pooling the genetic information from such a large population is what allowed us to look across the genome for possible culprits in AMD, even very small, very rare ones."

The researchers have now discovered a total of 52 genetic variations that are associated with AMD and are located among 34 loci, 16 of which had not been previously associated with AMD.

The study findings also bolster associations between AMD and two genes, CFH and TIMP3, which had each previously been linked to AMD. CFH was the very first disease-linked gene to be found through a genome-wide association study. TIMP3 had earlier been linked to Sorsby's fundus dystrophy, a rare disease that is similar to AMD clinically, but that tends to affect people before the age of 45.

For the first time the researchers also identified a variation specific to 'wet' AMD, which may point to reasons why therapy for this form of AMD is effective for some people but not everyone.

Additionally, 10 of the variations point to genes involved in maintaining the extracellular matrix, the non-living material amongst cells that provides structural support and nutrients. Researchers have theorised that abnormalities of the extracellular matrix occur in people with a subtype of AMD that develops without early-stage signs, or that quickly worsens before such signs are detected. If confirmed, a connection between AMD and these extracellular matrix genes may allow for predictive genetic tests and more effective therapies for people with this type of AMD.


Story Source:

Materials provided by University of Southampton. Note: Content may be edited for style and length.


Journal Reference:

  1. Lars G Fritsche, Wilmar Igl, Jessica N Cooke Bailey, Felix Grassmann, Sebanti Sengupta, Jennifer L Bragg-Gresham, Kathryn P Burdon, Scott J Hebbring, Cindy Wen, Mathias Gorski, Ivana K Kim, David Cho, Donald Zack, Eric Souied, Hendrik P N Scholl, Elisa Bala, Kristine E Lee, David J Hunter, Rebecca J Sardell, Paul Mitchell, Joanna E Merriam, Valentina Cipriani, Joshua D Hoffman, Tina Schick, Yara T E Lechanteur, Robyn H Guymer, Matthew P Johnson, Yingda Jiang, Chloe M Stanton, Gabriëlle H S Buitendijk, Xiaowei Zhan, Alan M Kwong, Alexis Boleda, Matthew Brooks, Linn Gieser, Rinki Ratnapriya, Kari E Branham, Johanna R Foerster, John R Heckenlively, Mohammad I Othman, Brendan J Vote, Helena Hai Liang, Emmanuelle Souzeau, Ian L McAllister, Timothy Isaacs, Janette Hall, Stewart Lake, David A Mackey, Ian J Constable, Jamie E Craig, Terrie E Kitchner, Zhenglin Yang, Zhiguang Su, Hongrong Luo, Daniel Chen, Hong Ouyang, Ken Flagg, Danni Lin, Guanping Mao, Henry Ferreyra, Klaus Stark, Claudia N von Strachwitz, Armin Wolf, Caroline Brandl, Guenther Rudolph, Matthias Olden, Margaux A Morrison, Denise J Morgan, Matthew Schu, Jeeyun Ahn, Giuliana Silvestri, Evangelia E Tsironi, Kyu Hyung Park, Lindsay A Farrer, Anton Orlin, Alexander Brucker, Mingyao Li, Christine A Curcio, Saddek Mohand-Saïd, José-Alain Sahel, Isabelle Audo, Mustapha Benchaboune, Angela J Cree, Christina A Rennie, Srinivas V Goverdhan, Michelle Grunin, Shira Hagbi-Levi, Peter Campochiaro, Nicholas Katsanis, Frank G Holz, Frédéric Blond, Hélène Blanché, Jean-François Deleuze, Robert P Igo, Barbara Truitt, Neal S Peachey, Stacy M Meuer, Chelsea E Myers, Emily L Moore, Ronald Klein, Michael A Hauser, Eric A Postel, Monique D Courtenay, Stephen G Schwartz, Jaclyn L Kovach, William K Scott, Gerald Liew, Ava G Tan, Bamini Gopinath, John C Merriam, R Theodore Smith, Jane C Khan, Humma Shahid, Anthony T Moore, J Allie McGrath, Reneé Laux, Milam A Brantley, Anita Agarwal, Lebriz Ersoy, Albert Caramoy, Thomas Langmann, Nicole T M Saksens, Eiko K de Jong, Carel B Hoyng, Melinda S Cain, Andrea J Richardson, Tammy M Martin, John Blangero, Daniel E Weeks, Bal Dhillon, Cornelia M van Duijn, Kimberly F Doheny, Jane Romm, Caroline C W Klaver, Caroline Hayward, Michael B Gorin, Michael L Klein, Paul N Baird, Anneke I den Hollander, Sascha Fauser, John R W Yates, Rando Allikmets, Jie Jin Wang, Debra A Schaumberg, Barbara E K Klein, Stephanie A Hagstrom, Itay Chowers, Andrew J Lotery, Thierry Léveillard, Kang Zhang, Murray H Brilliant, Alex W Hewitt, Anand Swaroop, Emily Y Chew, Margaret A Pericak-Vance, Margaret DeAngelis, Dwight Stambolian, Jonathan L Haines, Sudha K Iyengar, Bernhard H F Weber, Gonçalo R Abecasis, Iris M Heid. A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. Nature Genetics, 2015; DOI: 10.1038/ng.3448

Cite This Page:

University of Southampton. "New genetic clues to age-related macular degeneration." ScienceDaily. ScienceDaily, 21 December 2015. <www.sciencedaily.com/releases/2015/12/151221111433.htm>.
University of Southampton. (2015, December 21). New genetic clues to age-related macular degeneration. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2015/12/151221111433.htm
University of Southampton. "New genetic clues to age-related macular degeneration." ScienceDaily. www.sciencedaily.com/releases/2015/12/151221111433.htm (accessed May 23, 2017).

RELATED STORIES