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Long-term ozone exposure increases acute respiratory disease syndrome risks in critically ill

Date:
January 7, 2016
Source:
American Thoracic Society
Summary:
Critically ill patients who are exposed to higher daily levels of ozone are more likely to develop acute respiratory disease syndrome, according to a new study.
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Critically ill patients who are exposed to higher daily levels of ozone are more likely to develop acute respiratory disease syndrome (ARDS), according to a new study published online ahead of print in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine. ARDS is a life-threatening inflammatory lung illness in which patients fail to obtain enough oxygen to the lungs. While previous research has shown a clear association between cigarette smoke and ARDS, the study "Long-Term Ozone Exposure Increases the Risk of Developing the Acute Respiratory Distress Syndrome" by Lorraine Ware, MD, of Vanderbilt University School of Medicine and colleagues is the first to demonstrate a risk related to ozone.

The researchers analyzed exposure using a heterogenous group of 1558 critically ill patients from the Validating Acute Lung Injury Biomarkers for Diagnosis cohort. They found that as long-term ozone exposure increased, so did rates of ARDS, which developed in 563 patients. The association between ARDS risk and ozone exposure was greatest among trauma patients (n=552). In addition, "Ozone was significantly associated with ARDS only in current smokers and not in non-smokers," wrote the researchers.

"The generalizability of this most recent study is enhanced given the large and heterogenous cohort we had at our disposal," Dr. Ware said. "However, we acknowledge that future studies need to replicate the findings in more diverse geographic samples so that we may more confidently recommend guidelines for reducing ozone exposure and ARDS risk among this vulnerable group of patients."

As the potentially harmful health consequences of ozone exposure continue to draw more concern, the demand for more research will likely increase because this study as well as another study on ozone and mortality appearing in the same issue of the AJRCCM suggest the need for a stricter ozone standard.


Story Source:

The above post is reprinted from materials provided by American Thoracic Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Lorraine B. Ware, Zhiguo Zhao, Tatsuki Koyama, Addison K. May, Michael A. Matthay, Fred W Lurmann, John R Balmes, Carolyn S Calfee. Long-Term Ozone Exposure Increases the Risk of Developing the Acute Respiratory Distress Syndrome. American Journal of Respiratory and Critical Care Medicine, 2015; DOI: 10.1164/rccm.201507-1418OC

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American Thoracic Society. "Long-term ozone exposure increases acute respiratory disease syndrome risks in critically ill." ScienceDaily. ScienceDaily, 7 January 2016. <www.sciencedaily.com/releases/2016/01/160107094418.htm>.
American Thoracic Society. (2016, January 7). Long-term ozone exposure increases acute respiratory disease syndrome risks in critically ill. ScienceDaily. Retrieved July 28, 2016 from www.sciencedaily.com/releases/2016/01/160107094418.htm
American Thoracic Society. "Long-term ozone exposure increases acute respiratory disease syndrome risks in critically ill." ScienceDaily. www.sciencedaily.com/releases/2016/01/160107094418.htm (accessed July 28, 2016).

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