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Important associations between genetics, sleep behavior identified by study

Date:
January 12, 2016
Source:
Coriell Institute for Medical Research
Summary:
A research initiative exploring the utility of genetic information in the clinical setting has published a study and identified six noteworthy genes that affect human sleep duration. The focus of the paper was to identify the genes associated with sleep duration and validate the connection between sleep and several demographic and lifestyle factors, including age, gender, weight, ethnicity, exercise, smoking and alcohol.
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The Coriell Personalized Medicine Collaborative (CPMC), a research initiative exploring the utility of genetic information in the clinical setting, has published a study and identified six noteworthy genes that affect human sleep duration.

Available in Volume 168, Issue 8 of the American Journal of Medical Genetics: Neuropsychiatric Genetics, the paper, titled, "Using the Coriell Personalized Medicine Collaborative Data to Conduct a Genome-Wide Association Study of Sleep Duration," draws on data collected from Coriell study participants to establish its findings.

"The fundamental biological purpose of sleep is still not understood," says Dr. Michael Christman, President and CEO of Coriell Institute. "But by engaging a diverse participant population and accumulating rich datasets, the CPMC research study is pursuing the type of insights that will help us learn more about sleep duration and, ultimately, improve human health."

The focus of the CPMC paper was to identify the genes associated with sleep duration and validate the connection between sleep and several demographic and lifestyle factors, including age, gender, weight, ethnicity, exercise, smoking and alcohol. Analysis implicated genes involved in ATP metabolism, circadian rhythms, narcolepsy, sleep cycles in mice, and bear hibernation.

"Researchers widely acknowledge that receiving inadequate sleep is a serious problem and can potentially contribute to a variety of health complications, such as a weakened immune system or an increased risk for obesity and diabetes," says Dr. Laura Scheinfeldt, lead author on the paper and a research scientist at Coriell.

"Individuals who average six hours or less are more susceptible to adverse health issues, and we found that participants enrolled in the CPMC study vary greatly in the amount of sleep they receive," says Dr. Scheinfeldt. "Effectively, by learning more about an individual's sleep patterns and considering environmental and genetic risk factors, physicians may one day be able to identify risks before they occur and target health solutions."

Founded in 2007, the CPMC research study involves a network of physicians, scientists, genetic counselors, and upwards of 8,500 volunteer participants. The study has produced more than 20 publications examining a range of complex human conditions, including cardiovascular disease, breast and lung cancer, and type I and II diabetes.

The Coriell study is committed to advancing the precision medicine discussion by aligning with progressive institutions, including the United States Air Force Medical Service, and sharing noteworthy data.


Story Source:

The above post is reprinted from materials provided by Coriell Institute for Medical Research. Note: Materials may be edited for content and length.


Journal Reference:

  1. Laura B. Scheinfeldt, Neda Gharani, Rachel S. Kasper, Tara J. Schmidlen, Erynn S. Gordon, Joseph P. Jarvis, Susan Delaney, Courtney J. Kronenthal, Norman P. Gerry and Michael F. Christman. You have full text access to this OnlineOpen article Using the Coriell Personalized Medicine Collaborative Data to conduct a genome-wide association study of sleep duration. American Journal of Medical Genetics: Neuropsychiatric Genetics, January 2016 DOI: 10.1002/ajmg.b.3236

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Coriell Institute for Medical Research. "Important associations between genetics, sleep behavior identified by study." ScienceDaily. ScienceDaily, 12 January 2016. <www.sciencedaily.com/releases/2016/01/160112125725.htm>.
Coriell Institute for Medical Research. (2016, January 12). Important associations between genetics, sleep behavior identified by study. ScienceDaily. Retrieved July 27, 2016 from www.sciencedaily.com/releases/2016/01/160112125725.htm
Coriell Institute for Medical Research. "Important associations between genetics, sleep behavior identified by study." ScienceDaily. www.sciencedaily.com/releases/2016/01/160112125725.htm (accessed July 27, 2016).

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