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First-of-its-kind study explains why rest is critical after a concussion

Date:
February 5, 2016
Source:
Georgetown University Medical Center
Summary:
Neuroscientists say rest -- for more than a day -- is critical for allowing the brain to reset neural networks and repair any short-term injury. This new study in mice also shows that repeated mild concussions with only a day to recover between injuries leads to mounting damage and brain inflammation that remains evident a year after injury.
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Doctors who order several days of rest after a person suffers a concussion are giving sound advice, say researchers, and new data from animal models explains why.

Georgetown University Medical Center neuroscientists say rest -- for more than a day -- is critical for allowing the brain to reset neural networks and repair any short-term injury. The new study in mice also shows that repeated mild concussions with only a day to recover between injuries leads to mounting damage and brain inflammation that remains evident a year after injury.

"It is good news that the brain can recover from a hit if given enough time to rest and recover. But on the flip side, we find that the brain does not undertake this rebalancing when impacts come too close together," says the study's lead researcher, Mark P. Burns, PhD, assistant professor of neuroscience at GUMC and director of the Laboratory for Brain Injury and Dementia.

This first-of-its-kind study, published in the March 2016 issue of American Journal of Pathology, modeled repeated mild head trauma as a means to investigate brain damage that occurs after a sports, military or domestic abuse injury.

Investigators developed a mouse model of repetitive, extremely mild concussive impacts. They compared the brain's response to a single concussion with an injury received daily for 30 days and one received weekly over 30 weeks.

Mice with a single insult temporarily lose 10-15 percent of the neuronal connections in their brains, but no inflammation or cell death resulted, Burns says. With three days rest, all neuronal connections were restored. This neuronal response is not seen in mice with daily concussions, but the pattern is restored when a week of rest is given between each insult, Burns says.

When a mild concussion occurred each day for a month, inflammation and damage to the brain's white matter resulted. "This damage became progressively worse for two months and remained apparent one year after the last impact," Burns says.

"The findings mirror what has been observed about such damage in humans years after a brain injury, especially among athletes," Burns says. "Studies have shown that almost all people with single concussions spontaneously recover, but athletes who play contact sports are much more susceptible to lasting brain damage. These findings help fill in the picture of how and when concussions and mild head trauma can lead to sustained brain damage."


Story Source:

The above post is reprinted from materials provided by Georgetown University Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Charisse N. Winston, Anastasia Noël, Aidan Neustadtl, Maia Parsadanian, David J. Barton, Deepa Chellappa, Tiffany E. Wilkins, Andrew D. Alikhani, David N. Zapple, Sonia Villapol, Emmanuel Planel, Mark P. Burns. Dendritic Spine Loss and Chronic White Matter Inflammation in a Mouse Model of Highly Repetitive Head Trauma. The American Journal of Pathology, 2016; DOI: 10.1016/j.ajpath.2015.11.006

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Georgetown University Medical Center. "First-of-its-kind study explains why rest is critical after a concussion." ScienceDaily. ScienceDaily, 5 February 2016. <www.sciencedaily.com/releases/2016/02/160205100445.htm>.
Georgetown University Medical Center. (2016, February 5). First-of-its-kind study explains why rest is critical after a concussion. ScienceDaily. Retrieved July 30, 2016 from www.sciencedaily.com/releases/2016/02/160205100445.htm
Georgetown University Medical Center. "First-of-its-kind study explains why rest is critical after a concussion." ScienceDaily. www.sciencedaily.com/releases/2016/02/160205100445.htm (accessed July 30, 2016).

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