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Hidden in plain sight: Well-known drug could yield new treatment for herpes viruses

Heart failure drug shown to also inhibit Epstein Barr virus by targeting a pathway common to all herpesviruses

Date:
March 14, 2016
Source:
University of Utah Health Sciences
Summary:
In a search for new antiviral drugs, scientists found that a common heart failure medicine, spironolactone, has an unexpected ability to block Epstein Barr virus (EBV). The drug blocks a key step in viral infection common to all herpesviruses, revealing that it could be developed into a new class of drug to treat infections caused by herpesviruses including herpes, shingles, and mono.
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Sankar Swaminathan, M.D., professor of internal medicine and chief of infectious diseases, and Dinesh Verma, Ph.D., research assistant professor of internal medicine, University of Utah School of Medicine.
Credit: University of Utah Health Sciences

Today, there is only one class of antiviral medicines against herpesviruses -- a family of viruses that cause mononucleosis, herpes, and shingles, among other illnesses -- meaning options for treating these infections are limited. If viruses become resistant to these frontline treatments, a growing problem particularly in clinical settings, there are no alternative drugs to serve as backup.

In a search for new drugs to treat viral infections, scientists from the University of Utah School of Medicine found that a medicine routinely used to treat heart failure, spironolactone, has an unexpected ability to block infection by Epstein Barr virus (EBV), a herpesvirus that causes mono and is associated with several human cancers. They find that the drug's antiviral properties stem from its ability to block a key step in viral infection that is common to all herpesviruses. Spironolactone's target is distinct from that of existing drugs, revealing that it could be developed into a new class of anti-herpesvirus drug.

"It's remarkable that a drug we have used safely in the clinic for over 50 years is also an effective EBV inhibitor," says senior author Sankar Swaminathan, M.D., chief of infections disease at University of Utah Health Care and professor of internal medicine. "It goes to show how basic research can reveal things we would never have found otherwise." In collaboration with research assistant professor of internal medicine Dinesh Virma, Ph.D., and Jacob Thompson, he published the study in the Proceedings of the National Academy of Sciences.

Swaminathan's team uncovered spironolactone's antiviral properties in a screen to identify drugs that work through a mechanism that is different from that of existing anti-herpesvirus drugs. Currently available drugs block a middle step of the viral infection cycle by inhibiting virus' ability to replicate DNA. They found that like these drugs, spironolactone can block EBV replication in cells, but it does so by targeting the so-called SM protein, required for a late step in the infection cycle.

Importantly, spironolactone's ability to block viral infection appears to be independent from its ability to treat heart failure. Previous studies showed that the drug treats heart failure through a different, metabolic mechanism. This study demonstrates that a drug similar to spironolactone shares its ability to treat heart failure but not its antiviral properties. Together the results suggest the two mechanisms are separable.

"We think there is great potential to modify this molecule so that it can work as an antiviral without having undesired side effects," explains Swaminathan. Spironolactone could be developed as a new medicine against EBV, a common and dangerous infection among transplant and other immunocompromised patients.

But because all herpesviruses depend on SM-like proteins to spread infection, the work also has broader implications. Spironolactone could be a template for a new class of drug directed against all herpesviruses.

"We have found a new therapeutic target for herpesviruses," says Swaminathan. "We think it can be developed it into a new class of antiviral drugs to help overcome the problem of drug resistant infections."


Story Source:

Materials provided by University of Utah Health Sciences. Note: Content may be edited for style and length.


Journal Reference:

  1. Dinesh Verma, Jacob Thompson, Sankar Swaminathan. Spironolactone blocks Epstein–Barr virus production by inhibiting EBV SM protein function. Proceedings of the National Academy of Sciences, 2016; 201523686 DOI: 10.1073/pnas.1523686113

Cite This Page:

University of Utah Health Sciences. "Hidden in plain sight: Well-known drug could yield new treatment for herpes viruses: Heart failure drug shown to also inhibit Epstein Barr virus by targeting a pathway common to all herpesviruses." ScienceDaily. ScienceDaily, 14 March 2016. <www.sciencedaily.com/releases/2016/03/160314161234.htm>.
University of Utah Health Sciences. (2016, March 14). Hidden in plain sight: Well-known drug could yield new treatment for herpes viruses: Heart failure drug shown to also inhibit Epstein Barr virus by targeting a pathway common to all herpesviruses. ScienceDaily. Retrieved May 26, 2017 from www.sciencedaily.com/releases/2016/03/160314161234.htm
University of Utah Health Sciences. "Hidden in plain sight: Well-known drug could yield new treatment for herpes viruses: Heart failure drug shown to also inhibit Epstein Barr virus by targeting a pathway common to all herpesviruses." ScienceDaily. www.sciencedaily.com/releases/2016/03/160314161234.htm (accessed May 26, 2017).

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