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Drug combination reduces polyps for patients with high risk for colorectal cancer

Date:
March 22, 2016
Source:
The JAMA Network Journals
Summary:
In a recent study, researchers randomly assigned 92 patients with familial adenomatous polyposis to the drugs sulindac twice daily and erlotinib daily (n = 46) or placebo (n = 46) for 6 months. The outcome of the study showed very positive results for those with a high risk of colorectal cancer
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In a study appearing in the March 22/29 issue of JAMA, Deborah W. Neklason, Ph.D., N. Jewel Samadder, M.D., M.S., of the Huntsman Cancer Institute, University of Utah, Salt Lake City, and colleagues randomly assigned 92 patients with familial adenomatous polyposis to the drugs sulindac twice daily and erlotinib daily (n = 46) or placebo (n = 46) for 6 months.

Familial adenomatous polyposis (FAP) is an inherited disorder, and patients with FAP are at markedly increased risk for duodenal (part of the small intestine) polyps and cancer. Surgical and endoscopic management of duodenal neoplasia is difficult and chemoprevention has not been successful.

The researchers found that sulindac in combination with erlotinib effectively reduced the total duodenal polyp burden and polyp number in participants with FAP compared with placebo. This effect was significant after 6 months of therapy.

Grade 1 and 2 adverse events were more common in the sulindac-erlotinib group, with an acne-like rash observed in 87 percent of participants receiving treatment and 20 percent of participants receiving placebo. "Adverse events may limit the use of these medications at the doses used in this study," the authors write.

"Further research is necessary to evaluate these preliminary findings in a larger study population with longer follow-up to determine whether the observed effects will result in improved clinical outcomes."


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Materials provided by The JAMA Network Journals. Note: Content may be edited for style and length.


Journal Reference:

  1. N. Jewel Samadder, Deborah W. Neklason, Kenneth M. Boucher, Kathryn R. Byrne, Priyanka Kanth, Wade Samowitz, David Jones, Sean V. Tavtigian, Michelle W. Done, Therese Berry, Kory Jasperson, Lisa Pappas, Laurel Smith, Danielle Sample, Rian Davis, Matthew K. Topham, Patrick Lynch, Elena Strait, Wendy McKinnon, Randall W. Burt, Scott K. Kuwada. Effect of Sulindac and Erlotinib vs Placebo on Duodenal Neoplasia in Familial Adenomatous Polyposis. JAMA, 2016; 315 (12): 1266 DOI: 10.1001/jama.2016.2522

Cite This Page:

The JAMA Network Journals. "Drug combination reduces polyps for patients with high risk for colorectal cancer." ScienceDaily. ScienceDaily, 22 March 2016. <www.sciencedaily.com/releases/2016/03/160322120034.htm>.
The JAMA Network Journals. (2016, March 22). Drug combination reduces polyps for patients with high risk for colorectal cancer. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2016/03/160322120034.htm
The JAMA Network Journals. "Drug combination reduces polyps for patients with high risk for colorectal cancer." ScienceDaily. www.sciencedaily.com/releases/2016/03/160322120034.htm (accessed May 23, 2017).

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