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New function of the chromosomal terminus, vital for human health, discovered

Date:
March 28, 2016
Source:
Osaka University
Summary:
A research group discovered a new function of the chromosomal terminus, which may lead to the clarification of the mechanism for developing abnormal telomere structure such as multiple malformation and mental retardation.
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Shugoshin binds with subtelomere and controls DNA.replication.
Credit: Image courtesy of Osaka University

A research group discovered a new function of the chromosomal terminus, which may lead to the clarification of the mechanism for developing abnormal telomere structure such as multiple malformation and mental retardation.

DNA forms chromosome by combining with various proteins and other matters. Telemere, the chromosome ends, is playing an inevitable role in maintaining the life including germ cells or cell senescence. Besides, the function of subtelomere, the telomere-adjacent region, has not yet been clarified although abnormal telomere structure such as multiple malformation and mental retardation exists.

A research group led by Junko Kanoh, Associate Professor at Institute for Protein Research, Osaka University in cooperation with the Graduate School of Science, Graduate School of Frontier Biosciences of Osaka University, National Institute of Information and Communications Technology, and The University of Tokyo elucidated a function of the telomere.

Specifically, this group found that a protein called Shugoshin binds with subtelomeres and that through which the proper gene expression in subtelomeres is maintained. This group also clarified that Shugoshin controls DNA replication (the process by which DNA makes a copy of itself during cell division) in subtelomeres as well as higher-order structure of chromosomes.

The clarification of the mystery of whether Shugoshin controls the subtelomeres or similar control systems work in humans as well may lead to the elucidation of a mechanism for developing abnormal telomere structure such as multiple malformation and mental retardation.


Story Source:

Materials provided by Osaka University. Note: Content may be edited for style and length.


Journal Reference:

  1. Sanki Tashiro, Tetsuya Handa, Atsushi Matsuda, Takuto Ban, Toru Takigawa, Kazumi Miyasato, Kojiro Ishii, Kazuto Kugou, Kunihiro Ohta, Yasushi Hiraoka, Hisao Masukata, Junko Kanoh. Shugoshin forms a specialized chromatin domain at subtelomeres that regulates transcription and replication timing. Nature Communications, 2016; 7: 10393 DOI: 10.1038/ncomms10393

Cite This Page:

Osaka University. "New function of the chromosomal terminus, vital for human health, discovered." ScienceDaily. ScienceDaily, 28 March 2016. <www.sciencedaily.com/releases/2016/03/160328085139.htm>.
Osaka University. (2016, March 28). New function of the chromosomal terminus, vital for human health, discovered. ScienceDaily. Retrieved May 27, 2017 from www.sciencedaily.com/releases/2016/03/160328085139.htm
Osaka University. "New function of the chromosomal terminus, vital for human health, discovered." ScienceDaily. www.sciencedaily.com/releases/2016/03/160328085139.htm (accessed May 27, 2017).

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