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New research paves way for improved individual treatment of patients with cancer

Research group has found new molecular sub-groups in early stages of bladder cancer

Date:
June 17, 2016
Source:
Aarhus University Hospital
Summary:
A new study has found new molecular sub-groups in early stages of bladder cancer. This improves the understanding of why some tumors develop aggressively and this discovery may lead to optimized treatment.
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This graphic illustrates mutations and bioinformatic analysis.
Credit: Jakob Skou, Philippe Lamy

Bladder cancer is a frequent disease affecting approximately 1,900 persons in Denmark annually. A high number of these patients only have superficial tumors in the bladder when the disease is diagnosed. For many years, this patient group will be examined frequently and during this time many get new tumors; some cases develop aggressively making it necessary to remove the bladder or receive chemotherapy.

A research team from Aarhus University Hospital and Aarhus University headed by professor Torben Ørntoft and professor Lars Dyrskjøt has been in charge of a larger European research project mapping the molecular mechanisms of early stages of bladder cancer in 460 patients in Denmark, Sweden, The Netherlands, Germany, Spain and Serbia. The researchers found that tumors can be divided into three primary classes with very different molecular and disease-developing characteristics. These findings may be important in risk assessment and subsequent choice of treatment.

The researchers found that bladder tumors from the molecular group with high risk of developing aggressive disease contain mutations in genes and molecular pathways often associated with later stages of the disease. Moreover, the researchers observed changes in genes involved in genome structure regulation in 86% of the tumors. This new knowledge can facilitate use of new drugs targeted at these specific changes.

"This study provides new and valuable insight into the biology of the tumors in the earliest stages of the disease. Clinical and pathological examinations of the individual tumors do not always reflect the risk of later disease aggressiveness. This study provides a tool for risk assessment of the patients and thus for providing optimal treatment," says professor Lars Dyrskjøt from Department of Molecular Medicine, Aarhus University Hospital.


Story Source:

Materials provided by Aarhus University Hospital. Note: Content may be edited for style and length.


Journal Reference:

  1. Hedegaard J, Lamy P, Nordentoft I, Algaba F, Høyer S, Ulhø BP3, Vang S, Reinert T, Hermann GG, Mogensen K, Thomsen MBH, Nielsen MM, Marquez M, Segersten U, Aine M, Höglund M, Birkenkamp-Demtröder K, Fristrup N, Borre M, Hartmann A, Stöhr R, Wach S, Keck B, Seitz AK, Nawroth R, Maurer T, Tulic T, Simic T, Junker K, Horstmann M, Harving N, Petersen AC, Calle ML, Steyerberg EW, Beukers W, van Kessel K, Jensen JB, Pedersen JS, Malmström PU, Malats N, Real FX, Zwarthoff EC, Ørntoft TF, and Dyrskjøt L. Comprehensive Transcriptional Analysis of Early-Stage Urothelial Carcinoma. Cancer Cell, July 2016 DOI: 10.1016/j.ccell.2016.05.004

Cite This Page:

Aarhus University Hospital. "New research paves way for improved individual treatment of patients with cancer: Research group has found new molecular sub-groups in early stages of bladder cancer." ScienceDaily. ScienceDaily, 17 June 2016. <www.sciencedaily.com/releases/2016/06/160617104917.htm>.
Aarhus University Hospital. (2016, June 17). New research paves way for improved individual treatment of patients with cancer: Research group has found new molecular sub-groups in early stages of bladder cancer. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2016/06/160617104917.htm
Aarhus University Hospital. "New research paves way for improved individual treatment of patients with cancer: Research group has found new molecular sub-groups in early stages of bladder cancer." ScienceDaily. www.sciencedaily.com/releases/2016/06/160617104917.htm (accessed May 23, 2017).

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