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New heart failure therapy could prevent substantial number of deaths, study finds

Date:
June 22, 2016
Source:
University of California - Los Angeles Health Sciences
Summary:
A study estimates that almost 28,500 deaths could be prevented each year in the US through use of a new FDA-approved class of cardiovascular medication that helps reduce mortality in patients diagnosed with heart failure and reduced ejection fraction, the percentage of blood pumped from the heart with each contraction.
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A UCLA-led study estimates that almost 28,500 deaths could be prevented each year in the U.S. through use of a new FDA-approved class of cardiovascular medication that helps reduce mortality in patients diagnosed with heart failure and reduced ejection fraction, the percentage of blood pumped from the heart with each contraction.

Previous studies have demonstrated that 'angiotensin receptor neprilysin inhibitor' (ARNI) therapy using a new class of medication (generic name: sacubitril and valsartan) reduces mortality in patients with heart failure and reduced ejection fraction. The therapy works by enhancing the body's protective hormonal systems while simultaneously inhibiting the overactive hormones that harm the heart.

In this study, researchers wanted to quantify the number of deaths that could be prevented or postponed with ARNI therapy. Researchers conducted the study by analyzing published data of patients who were eligible for the therapy, estimates of the number of people in the U.S. diagnosed with heart failure and reduced ejection fraction, and the numbers needed to treat with the medication to avert death.

More than 2.7 million patients in the United States have been diagnosed with heart failure and reduced ejection fraction. Of these patients, 84 percent (almost 2.3 million) are potential candidates for ARNI therapy. This study showed that, if ARNI therapy were comprehensively applied to eligible patients, it could potentially prevent 28,484 deaths each year.

"These findings support the timely implementation of ARNI therapy into routine clinical practice because this will have substantial impact on population health for patients with heart failure," said the study's lead author, Dr. Gregg Fonarow, the Eliot Corday Chair in Cardiovascular Medicine and Science, director of the Ahmanson-UCLA Cardiomyopathy Center and co-chief of the UCLA Division of Cardiology.


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Materials provided by University of California - Los Angeles Health Sciences. Note: Content may be edited for style and length.


Journal Reference:

  1. Thomas A. Gaziano, MD, MSc; Gregg C. Fonarow, MD; Brian Claggett, PhD; Wing W. Chan, MS; Celine Deschaseaux-Voinet, MPH; Stuart J. Turner, MPH; Jean L. Rouleau, MD; Michael R. Zile, MD; John J. V. McMurray, MD; Scott D. Solomon, MD. Cost-effectiveness Analysis of Sacubitril/Valsartan vs Enalapril in Patients With Heart Failure and Reduced Ejection Fraction. JAMA Cardiology, June 2016 DOI: 10.1001/jamacardio.2016.1747

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University of California - Los Angeles Health Sciences. "New heart failure therapy could prevent substantial number of deaths, study finds." ScienceDaily. ScienceDaily, 22 June 2016. <www.sciencedaily.com/releases/2016/06/160622114740.htm>.
University of California - Los Angeles Health Sciences. (2016, June 22). New heart failure therapy could prevent substantial number of deaths, study finds. ScienceDaily. Retrieved May 25, 2017 from www.sciencedaily.com/releases/2016/06/160622114740.htm
University of California - Los Angeles Health Sciences. "New heart failure therapy could prevent substantial number of deaths, study finds." ScienceDaily. www.sciencedaily.com/releases/2016/06/160622114740.htm (accessed May 25, 2017).

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