Scientists decipher a mechanism in serious skin infections

The group of scientists has been able to demonstrate that CA-MRSA strains can change their outer cell envelope by inserting increasing amounts of a long-chain sugar polymer, the cell wall teichoic acid. "It's well-known that CA-MRSA strongly increases the secretion of toxins, which plays a major role in the serious progression of skin infections," said Dr. Christopher Weidenmaier, the head of the research group. "We've now also been able to prove that the increased insertion of the sugar polymer into the cell envelope creates a change in the immune reaction in the case of skin infections. This," he added, "increased the ability of these aggressive bacteria to cause particularly serious skin infections in animal experiments. However, additional research is required to determine if the results also hold true in humans.

The authors were in a position to decipher the molecular mechanisms more precisely, which underlie the modification in the cell envelope. This will open up the possibility of deliberately preventing the modification process in serious skin infections caused by CA-MRSA strains in the future. "This kind of therapeutic approach would give the human immune system the chance to combat the infection more efficiently itself," Weidenmaier said. These so-called anti-virulence strategies have been increasingly explored in recent times; in this case, the pathogen itself is not attacked, but its pathogenic effect. "In contrast to classic antibiotic treatment, an anti-virulence strategy should lead to lower resistance rates," the scientist explained. "Because the bacterial cell is not killed off or inhibited in its growth, it is subject to less evolutionary pressure."