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Effects of a poor diet during pregnancy may be reversed in female adolescent offspring

Date:
February 24, 2017
Source:
Federation of American Societies for Experimental Biology
Summary:
Here's some good news if you are female: Research shows that in mice, what is eaten during adolescence or childhood development may alter long-term behavior and learning, and can even 'rescue' females from the negative effects on behavior resulting from a poor maternal diet during pregnancy.
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Here's some good news if you are female: Research published online in The FASEB Journal, shows that in mice, what is eaten during adolescence or childhood development may alter long-term behavior and learning, and can even "rescue" females from the negative effects on behavior resulting from a poor maternal diet during pregnancy.

"These are provocative findings," said Thoru Pederson, Ph.D., Editor-in-Chief of The FASEB Journal." So many effects during pregnancy have been touted as irreversible -- perhaps not always so. "

In their study Reyes and colleagues used four groups of female mice. The first group was fed a control diet during pregnancy and lactation. The second group was fed a high-fat diet during pregnancy and lactation. The third was also fed a nutrient-enriched diet during early life. The fourth group included offspring from the mice fed a high-fat diet that were fed the nutrient-enriched diet during early life. When all mice were adults, they were fed the same control diet for the remainder of their lives. Researchers then used operant behavior chambers (chambers in which a mouse must nose-poke into a hole to get a reward) to examine learning and motivation. They found that the female offspring who were fed the nutrient-enriched diet during early life learned faster and were more motivated to obtain the sugar reward. Furthermore, the nutrient supplementation also reversed some of the deficits observed due to high-fat feeding during pregnancy.


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Materials provided by Federation of American Societies for Experimental Biology. Note: Content may be edited for style and length.


Journal Reference:

  1. Sarah E. McKee, Nicola M. Grissom, Christopher T. Herdt, Teresa M. Reyes. Methyl donor supplementation alters cognitive performance and motivation in female offspring from high-fat diet–fed dams. The FASEB Journal, 2017; fj.201601172R DOI: 10.1096/fj.201601172R

Cite This Page:

Federation of American Societies for Experimental Biology. "Effects of a poor diet during pregnancy may be reversed in female adolescent offspring." ScienceDaily. ScienceDaily, 24 February 2017. <www.sciencedaily.com/releases/2017/02/170224160647.htm>.
Federation of American Societies for Experimental Biology. (2017, February 24). Effects of a poor diet during pregnancy may be reversed in female adolescent offspring. ScienceDaily. Retrieved May 28, 2017 from www.sciencedaily.com/releases/2017/02/170224160647.htm
Federation of American Societies for Experimental Biology. "Effects of a poor diet during pregnancy may be reversed in female adolescent offspring." ScienceDaily. www.sciencedaily.com/releases/2017/02/170224160647.htm (accessed May 28, 2017).

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