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Pinpointing the mechanisms that underlie emotional responses to pain

Date:
March 13, 2017
Source:
JCI Journals
Summary:
Prostaglandins been linked to the sensory perception of pain, but their role in the emotional response to pain is unclear. A new study has demonstrated that the aversive effects of inflammatory pain are driven by prostaglandin signaling specifically on serotonin-producing neurons in the brainstem.
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Pain serves as a warning signal to indicate the intensity and location of damage to the body. In addition to unpleasant sensations, painful events trigger negative emotional responses that may serve to reinforce pain-avoiding behaviors. However, in chronic inflammatory conditions, negative emotional states associated with long-term pain can put affected individuals at a higher risk for psychiatric complications such as depression or substance abuse.

Signaling by molecules called prostaglandins plays a key role in the body's response to inflammation. Prostaglandins been linked to the sensory perception of pain, but their role in the emotional response to pain is unclear. This week in the JCI, a study conducted by David Engblom's lab at Linköping University in Sweden has demonstrated that the aversive effects of inflammatory pain are driven by prostaglandin signaling specifically on serotonin-producing neurons in the brainstem.

When the researchers selectively blocked prostaglandin synthesis in neurons, mice displayed reduced aversive responses to inflammation-induced pain. Furthermore, mice lacking prostaglandin receptors on serotonin-producing neurons and mice lacking the serotonin transporter also exhibited less pain-avoidance behavior. Prostaglandin signaling in serotonin neurons was not required for aversive responses to high temperatures, suggesting that this pain-aversive signaling pathway is specific to inflammatory pain. These findings suggest that the effects of prostaglandin on serotonin signaling are key drivers of the emotional response to pain, implicating a pathway that may be targeted in future therapeutics for managing pain in chronic inflammatory conditions.


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Journal Reference:

  1. Anand Kumar Singh, Joanna Zajdel, Elahe Mirrasekhian, Nader Almoosawi, Isabell Frisch, Anna M. Klawonn, Maarit Jaarola, Michael Fritz, David Engblom. Prostaglandin-mediated inhibition of serotonin signaling controls the affective component of inflammatory pain. Journal of Clinical Investigation, 2017; DOI: 10.1172/JCI90678

Cite This Page:

JCI Journals. "Pinpointing the mechanisms that underlie emotional responses to pain." ScienceDaily. ScienceDaily, 13 March 2017. <www.sciencedaily.com/releases/2017/03/170313161848.htm>.
JCI Journals. (2017, March 13). Pinpointing the mechanisms that underlie emotional responses to pain. ScienceDaily. Retrieved May 26, 2017 from www.sciencedaily.com/releases/2017/03/170313161848.htm
JCI Journals. "Pinpointing the mechanisms that underlie emotional responses to pain." ScienceDaily. www.sciencedaily.com/releases/2017/03/170313161848.htm (accessed May 26, 2017).

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