New! Sign up for our free email newsletter.
Science News
from research organizations

Carbon monoxide improves effectiveness of antibiotic that fights stomach infection, study suggests

Date:
February 21, 2018
Source:
Georgia State University
Summary:
Carbon monoxide can improve the effectiveness of antibiotics, making bacteria more sensitive to antibiotic medication, suggests a new study that examined H. pylori bacteria in a culture dish.
Share:
FULL STORY

Carbon monoxide may improve the effectiveness of antibiotics, making bacteria more sensitive to antibiotic medication, according to a study led by Georgia State University.

Researchers paired carbon monoxide with the antibiotic metronidazole and found carbon monoxide enhanced the efficacy of the antibiotic against H. pylori, a type of bacteria that infects the stomach and causes peptic ulcers. The findings are published in the journal Organic Letters.

"We found that if you administer carbon monoxide together with an antibiotic called metronidazole, it can sensitize bacteria toward the same antibiotic by 25-fold," said Dr. Binghe Wang, Regents' Professor of Chemistry and director of the Center for Diagnostics & Therapeutics at Georgia State and a Georgia Research Alliance Eminent Scholar in Drug Discovery. "It makes the bacteria much, much more sensitive to the antibiotic.

"We always hear about the discussions of drug resistance. When we have drug resistance, it's not because these bacteria will not respond to antibiotics anymore. Most of the time, it means there is decreased sensitivity. If you can resensitize bacteria or sensitize them, then that would allow you to either use a smaller amount of antibiotic or use the same amount that would kill many, many more bacteria."

Carbon monoxide is infamous for its toxicity at high concentrations, but it also has promising potential as a medical gas. Produced naturally in the human body, carbon monoxide is essential for survival and plays an important role in reducing inflammation, promoting cell proliferation and regulating cellular immune response to pathogens. Studies have found carbon monoxide has antimicrobial effects.

In this study, the researchers developed a prodrug system that releases three components: carbon monoxide, an antibiotic (metronidazole) and a fluorescent molecule used to monitor the release of carbon monoxide. A prodrug is the precursor of a drug and must undergo a chemical conversion before becoming an active pharmacological agent. This prodrug system has a three-reaction sequence and becomes active when placed in water, which sets the reaction in motion.

They studied H. pylori bacteria in a culture dish and compared the effect of only the antibiotic metronidazole against the bacteria versus the prodrug system with metronidazole and carbon monoxide combined.

Co-authors of the study include Ladie Kimberly C. De La Cruz, Zhixiang Pan, Bingchen Yu and Xingyue Ji of Georgia State and Stéphane L. Benoit and Robert J. Maier of the University of Georgia.


Story Source:

Materials provided by Georgia State University. Note: Content may be edited for style and length.


Journal Reference:

  1. Ladie Kimberly C. De La Cruz, Stéphane L. Benoit, Zhixiang Pan, Bingchen Yu, Robert J. Maier, Xingyue Ji, Binghe Wang. Click, Release, and Fluoresce: A Chemical Strategy for a Cascade Prodrug System for Codelivery of Carbon Monoxide, a Drug Payload, and a Fluorescent Reporter. Organic Letters, 2018; 20 (4): 897 DOI: 10.1021/acs.orglett.7b03348

Cite This Page:

Georgia State University. "Carbon monoxide improves effectiveness of antibiotic that fights stomach infection, study suggests." ScienceDaily. ScienceDaily, 21 February 2018. <www.sciencedaily.com/releases/2018/02/180221180525.htm>.
Georgia State University. (2018, February 21). Carbon monoxide improves effectiveness of antibiotic that fights stomach infection, study suggests. ScienceDaily. Retrieved March 18, 2024 from www.sciencedaily.com/releases/2018/02/180221180525.htm
Georgia State University. "Carbon monoxide improves effectiveness of antibiotic that fights stomach infection, study suggests." ScienceDaily. www.sciencedaily.com/releases/2018/02/180221180525.htm (accessed March 18, 2024).

Explore More

from ScienceDaily

RELATED STORIES