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Integrated lead discovery: An evolving toolbox

Date:
June 15, 2018
Source:
SLAS (Society for Laboratory Automation and Screening)
Summary:
A new review article offers an informative guide to the established and emerging tools available for early drug discovery and screening, and provides illustrative scenarios demonstrating considerations that drive decisions on choice of lead discovery tactics.
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FULL STORY

A new SLAS Discovery review article by GlaxoSmithKline researchers in the U.S. and U.K. offers an informative guide to the established and emerging tools available for early drug discovery and screening, and provides illustrative scenarios demonstrating considerations that drive decisions on choice of lead discovery tactics.

While high-throughout screening (HTS) remains a mainstay in drug discovery, other approaches have emerged or evolved in the past decade that offer complementary strengths and weaknesses, and are increasingly applied in combination with, or in lieu of, HTS. Great success often can be achieved by combining different approaches in an integrated manner.

Leveridge et al. survey the landscape of lead discovery tactics that researchers use today and explain how this toolbox of approaches is evolving as new science emerges, such as in the areas of complex cellular models and computational techniques. Case studies illustrate how integration of techniques like DNA-encoded library screening (ELT) and HTS, phenotypic and target-based screening, and virtual screening (VS) with experimental approaches can lead to successful outcomes and provide insights and synergies that would never have been obtained through one technique alone.


Story Source:

Materials provided by SLAS (Society for Laboratory Automation and Screening). Note: Content may be edited for style and length.


Journal Reference:

  1. Melanie Leveridge, Chun-Wa Chung, Jeffrey W. Gross, Christopher B. Phelps, Darren Green. Integration of Lead Discovery Tactics and the Evolution of the Lead Discovery Toolbox. SLAS DISCOVERY: Advancing Life Sciences R&D, 2018; 247255521877850 DOI: 10.1177/2472555218778503

Cite This Page:

SLAS (Society for Laboratory Automation and Screening). "Integrated lead discovery: An evolving toolbox." ScienceDaily. ScienceDaily, 15 June 2018. <www.sciencedaily.com/releases/2018/06/180615154446.htm>.
SLAS (Society for Laboratory Automation and Screening). (2018, June 15). Integrated lead discovery: An evolving toolbox. ScienceDaily. Retrieved December 9, 2024 from www.sciencedaily.com/releases/2018/06/180615154446.htm
SLAS (Society for Laboratory Automation and Screening). "Integrated lead discovery: An evolving toolbox." ScienceDaily. www.sciencedaily.com/releases/2018/06/180615154446.htm (accessed December 9, 2024).

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