New! Sign up for our free email newsletter.
Science News
from research organizations

Nano-carrier releases drugs into damaged cells

Date:
July 26, 2018
Source:
Institute for Research in Biomedicine (IRB Barcelona)
Summary:
Scientists have designed a drug encapsulation system that selectively targets senescent cells. The study paves the way for therapeutic approaches to eliminate senescent cells in many diseases, such as pulmonary fibrosis and cancer.
Share:
FULL STORY

Senescent cells are damaged cells that do not perform their normal roles anymore but that are not dead -hence they are commonly known as zombi cells. These cells interfere with the functioning of the tissue in which they accumulate. Senescence is a cell program that is triggered by many types of damage and senescent cells are present in many diseases. They accumulate in diverse types of tissues during aging, thus contributing to the progressive deterioration associated to aging. Eliminating these zombi cells is one of the challenges facing science today.

In the Cellular Plasticity and Disease lab headed by the ICREA researcher Manuel Serrano at the Institute for Research in Biomedicine (IRB Barcelona) and supported by "la Caixa" Banking Foundation, the researchers devise strategies to eliminate senescent cells. In a study published in EMBO Molecular Medicine, they present a proof of principle of a drug delivery system with selectivity for tissues that harbour senescent cells.

In collaboration with a team headed by Ramón Martínez-Máñez at the Universidad Politécnica de Valencia, the IRB Barcelona scientists have exploited a particular hallmark of senescent cells in order to design a delivery system that specifically targets them. They have demonstrated its efficacy in cells in vitro and in two experimental mouse models, namely pulmonary fibrosis and cancer. These diseases are characterized by the presence of damaged cells, and in the case of cancer this is particularly true after treatment with chemotherapy.

In these models, the senescent cells take up the carrier more efficiently than other cells and once inside the cell the casing of the carrier degrades to release the drug cargo. When the nano-vehicles contained cytotoxic compounds, the senescent cells were killed and this resulted in therapeutic improvements in mice with pulmonary fibrosis or with cancer.

"This nano-carrier may pave the way for new therapeutic approaches for serious conditions, such as pulmonary fibrosis or to eliminate chemotherapy-induced senescent cells," explains Manuel Serrano. Another outcome of this study is that these nano-carriers could be used for diagnostic tests of senescence as they can transport a fluorescent compound or marker.


Story Source:

Materials provided by Institute for Research in Biomedicine (IRB Barcelona). Note: Content may be edited for style and length.


Journal Reference:

  1. Daniel Muñoz‐Espín, Miguel Rovira, Irene Galiana, Cristina Giménez, Beatriz Lozano‐Torres, Marta Paez‐Ribes, Susana Llanos, Selim Chaib, Maribel Muñoz‐Martín, Alvaro C Ucero, Guillermo Garaulet, Francisca Mulero, Stephen G Dann, Todd VanArsdale, David J Shields, Andrea Bernardos, José Ramón Murguía, Ramón Martínez‐Máñez, Manuel Serrano. A versatile drug delivery system targeting senescent cells. EMBO Molecular Medicine, 2018; e9355 DOI: 10.15252/emmm.201809355

Cite This Page:

Institute for Research in Biomedicine (IRB Barcelona). "Nano-carrier releases drugs into damaged cells." ScienceDaily. ScienceDaily, 26 July 2018. <www.sciencedaily.com/releases/2018/07/180726160744.htm>.
Institute for Research in Biomedicine (IRB Barcelona). (2018, July 26). Nano-carrier releases drugs into damaged cells. ScienceDaily. Retrieved April 17, 2024 from www.sciencedaily.com/releases/2018/07/180726160744.htm
Institute for Research in Biomedicine (IRB Barcelona). "Nano-carrier releases drugs into damaged cells." ScienceDaily. www.sciencedaily.com/releases/2018/07/180726160744.htm (accessed April 17, 2024).

Explore More

from ScienceDaily

RELATED STORIES