New! Sign up for our free email newsletter.
Science News
from research organizations

No sweat required: Hypertension treatment mimics effect of exercise

By targeting the liver, scientists open door to new way of treating high blood pressure

Date:
October 16, 2018
Source:
University of Toledo
Summary:
By studying a chemical produced predominately in the liver, hypertension researchers have found a novel approach to lower blood pressure, even without reducing sodium intake or increasing exercise.
Share:
FULL STORY

Couch potatoes rejoice -- there might be a way to get the blood pressure lowering benefits of exercise in pill form.

Hypertension researchers at The University of Toledo have shown that by increasing the body's supply of beta hydroxybutyrate, a chemical produced predominantly by the liver, it is possible to regulate high blood pressure without reducing sodium intake or increasing exercise.

"Our team found that high salt consumption lowered levels of circulating beta hydroxybutyrate. When we put beta hydroxybutyrate back in the system, normal blood pressure is restored," said Dr. Bina Joe, Distinguished University Professor and chair of UT's Department of Physiology and Pharmacology and director of the Center for Hypertension and Precision Medicine. "We have an opportunity to control salt-sensitive hypertension without exercising."

The team's findings were published Tuesday in the Oct. 16 issue of the life sciences journal Cell Reports.

Beta hydroxybutyrate is a ketone body produced in the liver from the metabolism of fatty acids. It had not been previously explored as a method for controlling blood pressure, but the UT researchers noted a number of intriguing connections between how the body produces beta hydroxybutyrate and environmental factors known to raise or lower blood pressure.

"As we searched through the literature we saw beta hydroxybutyrate has been observed increasing with exercise or calorie restriction. Both of those activities also reduce blood pressure. The key piece of our discovery is we now know that beta hydroxybutyrate decreases with salt consumption. This is a novel mechanism by which salt is tied to an increase in blood pressure," said Saroj Chakraborty, a fourth-year PhD student in the UT Department of Physiology and Pharmacology and the paper's lead author.

To test its hypothesis, the team led by Chakraborty and Joe developed a study in which they fed lab rats a chemical called 1,3-butanediol.

When that supplement reaches the liver, enzymes convert it to beta hydroxybutyrate. From there, it goes to the kidney where it was shown to reduce inflammation commonly associated with hypertension -- and significantly decrease blood pressure in the process.

"By fixing the kidney it is indirectly contributing to the lowering of blood pressure. There could be many other organs that it is impacting," Joe said. "We are studying the heart, blood vessels, brain and other organ systems. But this paper says that this molecule, predominately made in the liver, goes to the kidney, fixes kidney damage and controls your blood pressure."

Joe noted that controlling function of the liver to regulate blood pressure is a new concept for researchers.

UT has received a provisional patent on the concept. Researchers in Joe's lab next want to compare the level of beta hydroxybutyrate in hypertensive patients against those without high blood pressure. Further studies also will determine how much 1,3-butanediol is needed to modulate blood pressure and whether it might cause any potential damage to other organs.

Once the team collects that data, the researchers hope to secure funding for a clinical trial.

While lowering blood pressure without hitting the gym might sound appealing to those averse to breaking a sweat, it also could prove beneficial to those who aren't able to exercise.

"There are certain patients who are not able to exercise for various reasons. This could prove to be a legitimate alternative for those individuals," Chakraborty said.


Story Source:

Materials provided by University of Toledo. Original written by Tyrel Linkhorn. Note: Content may be edited for style and length.


Journal Reference:

  1. Saroj Chakraborty, Sarah Galla, Xi Cheng, Ji-Youn Yeo, Blair Mell, Vishal Singh, BengSan Yeoh, Piu Saha, Anna V. Mathew, Matam Vijay-Kumar, Bina Joe. Salt-Responsive Metabolite, β-Hydroxybutyrate, Attenuates Hypertension. Cell Reports, 2018; 25 (3): 677 DOI: 10.1016/j.celrep.2018.09.058

Cite This Page:

University of Toledo. "No sweat required: Hypertension treatment mimics effect of exercise." ScienceDaily. ScienceDaily, 16 October 2018. <www.sciencedaily.com/releases/2018/10/181016132006.htm>.
University of Toledo. (2018, October 16). No sweat required: Hypertension treatment mimics effect of exercise. ScienceDaily. Retrieved March 28, 2024 from www.sciencedaily.com/releases/2018/10/181016132006.htm
University of Toledo. "No sweat required: Hypertension treatment mimics effect of exercise." ScienceDaily. www.sciencedaily.com/releases/2018/10/181016132006.htm (accessed March 28, 2024).

Explore More

from ScienceDaily

RELATED STORIES