New! Sign up for our free email newsletter.
Science News
from research organizations

Rare gene mutations may prevent heart disease

Date:
May 13, 2019
Source:
Boston University School of Medicine
Summary:
A kind of rare gene mutation may prevent heart disease, according to a new study. The study finds that protein-truncating variants in the apolipoprotein B (APOB) gene are linked to lower triglyceride and LDL cholesterol levels, and lower the risk of coronary heart disease by 72 percent.
Share:
FULL STORY

Targeting apolipoprotein B (APOB) gene has not been tested in clinical trials for cardiovascular outcomes because of risk of fatty liver disease, but naturally-occurring mutation suggests it may be effective.

A kind of rare gene mutation may prevent heart disease, according to a new study co-led by a Boston University School of Public Health (BUSPH) researcher. Published in the journal Circulation: Genomic and Precision Medicine, the study finds that protein-truncating variants in the apolipoprotein B (APOB) gene are linked to lower triglyceride and LDL cholesterol levels, and lower the risk of coronary heart disease by 72 percent.

Protein-truncating variants in the APOB gene are among the causes of a disorder called familial hypobetalipoproteinemia (FHBL), which causes a person's body to produce less low-density lipoproteins (LDL) and triglyceride-rich lipoproteins. People with FHBL generally have very low LDL cholesterol, but are at high risk of fatty liver disease. "An approved drug, Mipomersen, mimics the effects of having one of these variants in APOB, but due to the risk of fatty liver disease, clinical trials for cardiovascular outcomes won't be done," says study co-lead author Dr. Gina Peloso, assistant professor of biostatistics at BUSPH. "Using genetics, we provided evidence that targeting this gene could reduce the risk of coronary heart disease."

The researchers sequenced the APOB gene in members of 29 Japanese families with FHBL. Eight of the Japanese families had protein-truncating variants in APOB, and individuals with one of those variants had LDL cholesterol levels 55 mg/DL lower and triglyceride levels 53 percent lower than individuals who did not have an APOB variant.

The researchers also sequenced the APOB gene in 57,973 participants of a dozen coronary heart disease case-control studies of people with African, European, and South Asian ancestries, 18,442 of whom had early-onset coronary heart disease. Again, they found that people with these APOB gene variants had lower LDL cholesterol and triglyceride levels. Only 0.038 percent of the people with coronary heart disease carried an APOB variant, while 0.092 percent of those without coronary heart disease did, indicating that carrying gene variants in APOB reduces the risk of coronary heart disease.


Story Source:

Materials provided by Boston University School of Medicine. Note: Content may be edited for style and length.


Journal Reference:

  1. Gina M. Peloso , Akihiro Nomura , Amit V. Khera , Mark Chaffin , Hong-Hee Won , Diego Ardissino , John Danesh , Heribert Schunkert , James G. Wilson , Nilesh Samani , Jeanette Erdmann , Ruth McPherson , Hugh Watkins , Danish Saleheen , Shane McCarthy , Tanya M. Teslovich , Joseph B. Leader , H. Lester Kirchner , Jaume Marrugat , Atsushi Nohara , Masaaki Kawashiri , Hayato Tada , Frederick E. Dewey , David J. Carey , Aris Baras , and Sekar Kathiresan. Rare Protein-truncating Variants in APOB, Lower LDL-C, and Protection Against Coronary Heart Disease. Circulation: Genomic and Precision Medicine, 2019 DOI: 10.1161/CIRCGEN.118.002376

Cite This Page:

Boston University School of Medicine. "Rare gene mutations may prevent heart disease." ScienceDaily. ScienceDaily, 13 May 2019. <www.sciencedaily.com/releases/2019/05/190513123114.htm>.
Boston University School of Medicine. (2019, May 13). Rare gene mutations may prevent heart disease. ScienceDaily. Retrieved March 28, 2024 from www.sciencedaily.com/releases/2019/05/190513123114.htm
Boston University School of Medicine. "Rare gene mutations may prevent heart disease." ScienceDaily. www.sciencedaily.com/releases/2019/05/190513123114.htm (accessed March 28, 2024).

Explore More

from ScienceDaily

RELATED STORIES