Mar. 10, 2023 Researchers have identified a new therapeutic target that could lead to more effective treatment of ...
Feb. 27, 2023 Scientists know that TDP-43, which helps regulate processing of RNA, may be responsible for the death of nerve cells in ALS and frontotemporal dementia. And a study suggests that a common ...
Feb. 2, 2023 A new microscopic technique allows for the real-time study of RNA G-quadruplexes in living cells, with implications for the fight against amyotrophic lateral ...
Dec. 1, 2022 Scientists have taken a key step toward better understanding neurodegenerative diseases by using a suite of biophysical techniques to learn more about a motor protein whose malfunction is associated ...
Sep. 21, 2022 An international phase 3 clinical trial for a rare, inherited form of ALS showed that an investigational drug, known as tofersen, reduced molecular signs of disease, but at six months did not improve ...
Sep. 21, 2022 Scientists believe a new genetically-targeted therapy to treat motor neurone disease (MND) could be a turning point for patient care, after the results of a Phase 3 clinical trial showed significant ...
Aug. 30, 2022 Researchers have developed the first mouse model for a mitochondrial tRNALeu mutation, showing that the associated metabolic disorder results from faulty RNA ...
June 22, 2022 The immune system may play a fundamental role along with the central nervous system in amyotrophic lateral sclerosis (ALS), also known as 'Lou Gehrig's disease,' researchers ...
June 21, 2022 Amyotrophic lateral sclerosis (ALS) is a progressive disease of the nervous system. It affects nerve cells in the brain and spinal cord called motor neurons. Motor neurons control muscle movement and ...
May 18, 2022 New preclinical research on the experimental drug, NU-9, to treat ALS shows it is more effective than existing FDA-approved drugs for the disease. More importantly, NU-9 has an enhanced effect when ...
Mar. 29, 2022 Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects as many as 30,000 people in the United States, with 5,000 new cases diagnosed each year. It weakens muscles over time, ...
Feb. 28, 2022 Researchers from two independent research teams have discovered how the mislocalization of a protein, known as TDP-43, alters the genetic instructions for UNC13A, providing a possible therapeutic ...
Feb. 23, 2022 A pioneering new study has revealed, for the first time, why a common genetic variant worsens disease outcomes for people with the devastating adult-onset neurodegenerative diseases amyotrophic ...
Jan. 26, 2022 In a new meta-analysis of available ALS literature, researchers explore environmental influences potentially linked ALS disease, using rigorous quantitative methods. The study also examines the ...
Jan. 18, 2022 Scientists have revealed harmful changes in supporting cells, called astrocytes, in amyotrophic lateral sclerosis ...
Dec. 8, 2021 Scientists have determined the structure of the molecule associated with amyotrophic lateral sclerosis (ALS) and multiple other neurodegenerative diseases. The researchers say this discovery could ...
Dec. 2, 2021 The brain is indeed a target for treating ALS (amyotrophic lateral sclerosis), scientists have discovered. This flips a long-standing belief the disease starts in the spinal motor neurons and any ...
Nov. 19, 2021 Riluzole, a drug approved to treat amyotrophic lateral sclerosis (ALS), a disease affecting nerve cells controlling movement, could slow the gradual loss of a particular brain cell that occurs in ...
Nov. 15, 2021 Investigators found elevated levels of tau and a phosphorylated form of the tau protein in brain tissue from deceased people who had amyotrophic lateral sclerosis (ALS) and carried a mutation in the ...
Nov. 10, 2021 Investigators have found that an abnormal form of the tau protein is present in brain tissue from deceased patients who had amyotrophic lateral sclerosis (ALS). Cells that were grown in contact with ...