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Social isolation stresses rodents

Researchers propose new housing approaches to strengthen pre-clinical trials

Date:
July 22, 2019
Source:
Society for Neuroscience
Summary:
The traditional method of housing mice and rats alone increases stress and worsens epilepsy, according to a new study. The added stress could complicate results of pre-clinical drug trials.
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The traditional method of housing mice and rats alone increases stress and worsens epilepsy, according to a new study published in eNeuro. The added stress could complicate results of pre-clinical drug trials.

Rodents are typically housed alone to prevent aggressive behaviors and simplify data collection. However, rats and mice are social animals, and isolation causes stress that could be a confounding factor in studies.

eNeuro Editor-in-Chief Christophe Bernard and colleagues examined how epileptic and healthy mice and rats fared in social or isolated housing conditions. They found that the isolated, healthy rodents displayed higher levels of stress and anxiety compared to the healthy rodents living in groups. Epileptic rodents also had more severe seizures when they were isolated, likely due to the increased stress of their environment.

These findings emphasize the need to recognize housing conditions as an important factor during experimental design and data analysis, since increased stress could interfere with results. Because of this, previously unsuccessful drugs might have failed pre-clinical trials due to the increased stress of the rodents and could still be viable treatments.


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Materials provided by Society for Neuroscience. Note: Content may be edited for style and length.


Journal Reference:

  1. H Manouze, A Ghestem, V Poillerat, M Bennis, S Ba-M’hamed, JJ Benoliel, C Becker, C Bernard. Effects of single cage housing on stress, cognitive and seizure parameters in the rat and mouse pilocarpine models of epilepsy. eneuro, 2019; ENEURO.0179-18.2019 DOI: 10.1523/ENEURO.0179-18.2019

Cite This Page:

Society for Neuroscience. "Social isolation stresses rodents." ScienceDaily. ScienceDaily, 22 July 2019. <www.sciencedaily.com/releases/2019/07/190722132452.htm>.
Society for Neuroscience. (2019, July 22). Social isolation stresses rodents. ScienceDaily. Retrieved April 18, 2024 from www.sciencedaily.com/releases/2019/07/190722132452.htm
Society for Neuroscience. "Social isolation stresses rodents." ScienceDaily. www.sciencedaily.com/releases/2019/07/190722132452.htm (accessed April 18, 2024).

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