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Protective antibodies identified for rare, polio-like disease in children

Date:
July 3, 2020
Source:
Purdue University
Summary:
Researchers have isolated human monoclonal antibodies that potentially can prevent a rare but devastating polio-like illness in children linked to a respiratory viral infection.
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Researchers at Vanderbilt University Medical Center, Purdue University and the University of Wisconsin-Madison have isolated human monoclonal antibodies that potentially can prevent a rare but devastating polio-like illness in children linked to a respiratory viral infection.

The illness, called acute flaccid myelitis (AFM), causes sudden weakness in the arms and legs following a fever or respiratory illness. More than 600 cases have been identified since the U.S. Centers for Disease Control and Prevention began tracking the disease in 2014.

There is no specific treatment for AFM, which tends to strike in the late summer or early fall and which has been associated with some deaths. However, the disease has recently been linked to a group of respiratory viruses called enterovirus D68 (EV-D68).

Researchers at the Vanderbilt Vaccine Center isolated antibody-producing blood cells from the blood of children who had previously been infected by EV-D68. By fusing the blood cells to fast-growing myeloma cells, the researchers were able to generate a panel of monoclonal antibodies that potently neutralized the virus in laboratory studies.

Colleagues at Purdue determined the structure of the antibodies, which shed light on how they specifically recognize and bind to EV-D68. One of the antibodies protected mice from respiratory and neurologic disease when given either before or after infection by the enterovirus.

The study was supported by National Institutes of Health grants HL069765, AI117905, HL070831, AI104317 and AI011219, and the Center for Structural Genomics of Infectious Diseases.


Story Source:

Materials provided by Purdue University. Note: Content may be edited for style and length.


Journal Reference:

  1. Matthew R. Vogt, Jianing Fu, Nurgun Kose, Lauren E. Williamson, Robin Bombardi, Ian Setliff, Ivelin S. Georgiev, Thomas Klose, Michael G. Rossmann, Yury A. Bochkov, James E. Gern, Richard J. Kuhn, James E. Crowe. Human antibodies neutralize enterovirus D68 and protect against infection and paralytic disease. Science Immunology, 2020; 5 (49): eaba4902 DOI: 10.1126/sciimmunol.aba4902

Cite This Page:

Purdue University. "Protective antibodies identified for rare, polio-like disease in children." ScienceDaily. ScienceDaily, 3 July 2020. <www.sciencedaily.com/releases/2020/07/200703141146.htm>.
Purdue University. (2020, July 3). Protective antibodies identified for rare, polio-like disease in children. ScienceDaily. Retrieved June 12, 2024 from www.sciencedaily.com/releases/2020/07/200703141146.htm
Purdue University. "Protective antibodies identified for rare, polio-like disease in children." ScienceDaily. www.sciencedaily.com/releases/2020/07/200703141146.htm (accessed June 12, 2024).

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