New! Sign up for our free email newsletter.
Science News
from research organizations

Using contrast MRI after a heart attack could increase survival

May 11, 2021
University of Surrey
A new study has revealed that treatment for heart attacks could be improved thanks to a novel method of evaluating heart function using contrast-based MRI scans.

According to the British Heart Foundation, heart and circulatory diseases cause more than a quarter (27 per cent) of all deaths in the UK, which equates to more than 160,000 deaths each year -- or one death every three minutes.

The research, published in the top science journal Advanced Science, found that injection of the trace mineral manganese could enhanced MRI scans so that they provided more accurate details of heart function than traditional MRI methods.

These findings, if confirmed in human subjects, could have major implications for the treatment of heart attack patients. The findings could also be of great use in the preclinical evaluation of treatments for patients who suffer from cardiac ischemia -- a reduction in blood supply to the heart muscle that could lead to cardiac arrest.

The study also suggests that if manganese-enhanced MRI is performed within the first few hours of a heart attack it could be used to determine the optimal treatment regime for individual patients -- helping to regulate changes in the cardiac muscle and thereby further improving survival chances. Findings were evaluated by examining the infarct size and blood supply at three key intervals: one hour, one day and 14 days after a myocardial infarction was induced.

Dr Patrizia Camelliti, Principal Investigator and Senior Lecturer in Cardiovascular Science at the University of Surrey, said:

"Magnetic resonance imaging (MRI) is increasingly used to diagnose and give information on heart conditions. This research using mice allows us to measure the health status of the heart muscle rapidly after a heart attack and could provide important information for optimising treatments in patients."

Story Source:

Materials provided by University of Surrey. Note: Content may be edited for style and length.

Journal Reference:

  1. Nur Hayati Jasmin, May Zaw Thin, Robert D. Johnson, Laurence H. Jackson, Thomas A. Roberts, Anna L. David, Mark F. Lythgoe, Philip C. Yang, Sean M. Davidson, Patrizia Camelliti, Daniel J. Stuckey. Myocardial Viability Imaging using Manganese‐Enhanced MRI in the First Hours after Myocardial Infarction. Advanced Science, 2021; 2003987 DOI: 10.1002/advs.202003987

Cite This Page:

University of Surrey. "Using contrast MRI after a heart attack could increase survival." ScienceDaily. ScienceDaily, 11 May 2021. <>.
University of Surrey. (2021, May 11). Using contrast MRI after a heart attack could increase survival. ScienceDaily. Retrieved November 29, 2023 from
University of Surrey. "Using contrast MRI after a heart attack could increase survival." ScienceDaily. (accessed November 29, 2023).

Explore More
from ScienceDaily