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Marijuana for medical use may result in rapid onset of cannabis use disorder

The hype over medical marijuana for treating health problems may be exaggerated, researchers find.

March 18, 2022
Massachusetts General Hospital
A new study shows that using cannabis products to treat pain, anxiety and depression failed to improve these symptoms while doubling the risk of developing the addictive symptoms of cannabis use disorder. People seeking cannabis to treat symptoms of anxiety and depression were at greatest risk of CUD. Contrary to evidence-based medicine, people with medical marijuana cards choose their own products and dosing, suggesting the need for better controls over dispensing, use, and professional follow-up of these patients.

Obtaining a medical marijuana card (MMC) to use cannabis products to treat pain, anxiety, or depression symptoms led to the onset of cannabis use disorder (CUD) in a significant minority of individuals while failing to improve their symptoms, according to a study by Massachusetts General Hospital (MGH) researchers and published in JAMA Network Open. Researchers found that individuals at greatest risk of developing the addictive symptoms of CUD were those seeking relief from anxiety and depression, suggesting the need for stronger safeguards over the dispensing, use, and professional follow-up of people who legally obtain cannabis through MMCs.

"There have been many claims about the benefits of medical marijuana for treating pain, insomnia, anxiety and depression, without sound scientific evidence to support them," says lead author Jodi Gilman, PhD, with the Center for Addiction Medicine at MGH. "In this first study of patients randomized to obtain medical marijuana cards, we learned there can be negative consequences to using cannabis for medical purposes. People with pain, anxiety or depression symptoms failed to report any improvements, though those with insomnia experienced improved sleep." Particularly disturbing to Gilman was the fact individuals with symptoms of anxiety or depression -- the most common conditions for which medical cannabis is sought -- were most vulnerable to developing cannabis use disorder. CUD symptoms include the need for more cannabis to overcome drug tolerance, and continued use despite physical or psychological problems caused by the cannabis."

"Medical" cannabis has surged in popularity as 36 states and the District of Columbia have commercialized its use (as of December 2021) for myriad health conditions through medical marijuana cards. These cards require written approval of a licensed physician who, under the current system, is typically not the patient's primary care provider but a "cannabis doctor" who may provide authorization to patients with only a cursory examination, no recommendations for alternative treatments, and no follow-up. Indeed, the medical marijuana industry functions outside regulatory standards that apply to most fields of medicine.

MGH researchers began their trial in 2017 with 269 adults (average age of 37) from the greater Boston area who were interested in obtaining a medical marijuana card. One group was allowed to get MMCs immediately, while the second group, designed to serve as a control, was asked to wait 12 weeks before obtaining a card. Both groups were tracked over 12 weeks. The team found that the odds of developing CUD were nearly two times higher in the MMC cohort than in the wait list control group, and that by week 12, 10 percent of the MMC group had developed a CUD diagnosis, with the number rising to 20 percent in those seeking a card for anxiety or depression.

"Our study underscores the need for better decision-making about whether to begin to use cannabis for specific medical complaints, particularly mood and anxiety disorders, which are associated with an increased risk of cannabis use disorder," says Gilman. Regardless of the specific health condition for which cannabis is sought, Gilman believes that regulation and distribution of cannabis to people with medical marijuana cards must be greatly improved. "There needs to be better guidance to patients around a system that currently allows them to choose their own products, decide their own dosing, and often receive no professional follow-up care."

Gilman is associate professor of Psychiatry at Harvard Medical School (HMS). Senior author A. Eden Evins, MD, is the Cox Family Professor of Psychiatry at HMS.

The study was funded by the National Institute on Drug Abuse (NIDA).

Story Source:

Materials provided by Massachusetts General Hospital. Note: Content may be edited for style and length.

Journal Reference:

  1. Jodi M. Gilman, Randi M. Schuster, Kevin W. Potter, William Schmitt, Grace Wheeler, Gladys N. Pachas, Sarah Hickey, Megan E. Cooke, Alyson Dechert, Rachel Plummer, Brenden Tervo-Clemmens, David A. Schoenfeld, A. Eden Evins. Effect of Medical Marijuana Card Ownership on Pain, Insomnia, and Affective Disorder Symptoms in Adults. JAMA Network Open, 2022; 5 (3): e222106 DOI: 10.1001/jamanetworkopen.2022.2106

Cite This Page:

Massachusetts General Hospital. "Marijuana for medical use may result in rapid onset of cannabis use disorder." ScienceDaily. ScienceDaily, 18 March 2022. <>.
Massachusetts General Hospital. (2022, March 18). Marijuana for medical use may result in rapid onset of cannabis use disorder. ScienceDaily. Retrieved April 17, 2024 from
Massachusetts General Hospital. "Marijuana for medical use may result in rapid onset of cannabis use disorder." ScienceDaily. (accessed April 17, 2024).

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