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Preterm birth more likely with exposure to phthalates

Date:
July 11, 2022
Source:
NIH/National Institute of Environmental Health Sciences
Summary:
Pregnant women who were exposed to multiple phthalates during pregnancy had an increased risk of preterm birth, according to new research. Phthalates are chemicals used in personal care products, such as cosmetics, as well as in solvents, detergents, and food packaging.
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Pregnant women who were exposed to multiple phthalates during pregnancy had an increased risk of preterm birth, according to new research by the National Institutes of Health. Phthalates are chemicals used in personal care products, such as cosmetics, as well as in solvents, detergents, and food packaging.

After analyzing data from more than 6,000 pregnant women in the United States, researchers found that women with higher concentrations of several phthalate metabolites in their urine were more likely to deliver their babies preterm, which is delivering three or more weeks before a mother's due date.

"Having a preterm birth can be dangerous for both baby and mom, so it is important to identify risk factors that could prevent it," said Kelly Ferguson, Ph.D., an epidemiologist at the National Institute of Environmental Health Sciences (NIEHS), part of NIH, and the senior author on the study published in the journal JAMA Pediatrics.

In this study, the largest study to date on this topic, Ferguson and her team pooled data from 16 studies conducted across the United States that included individual participant data on prenatal urinary phthalate metabolites (representing exposure to phthalates) as well as the timing of delivery. Researchers analyzed data from a total of 6,045 pregnant women who delivered between 1983-2018. Nine percent, or 539, of the women in the study delivered preterm. Phthalate metabolites were detected in more than 96% of urine samples.

Higher concentrations of most phthalate metabolites examined were associated with slightly higher odds of preterm birth. Exposure to four of the 11 phthalates found in the pregnant women was associated with a 14-16% greater probability of having a preterm birth. The most consistent findings were for exposure to a phthalate that is used commonly in personal care products like nail polish and cosmetics.

The researchers also used statistical models to simulate interventions that reduce phthalate exposures. They found that reducing the mixture of phthalate metabolite levels by 50% could prevent preterm births by 12% on average. Interventions targeting behaviors, such as trying to select phthalate-free personal care products (if listed on label), voluntary actions from companies to reduce phthalates in their products, or changes in standards and regulations could contribute to exposure reduction and protect pregnancies.

"It is difficult for people to completely eliminate exposure to these chemicals in everyday life, but our results show that even small reductions within a large population could have positive impacts on both mothers and their children," said Barrett Welch, Ph.D., a postdoctoral fellow at NIEHS and first author on the study.

Eating fresh, home-cooked food, avoiding processed food that comes in plastic containers or wrapping, and selecting fragrance-free products or those labeled "phthalate-free," are examples of things people can do that may reduce their exposures. Changes to the amount and types of products that contain phthalates could also reduce exposures.

The researchers are conducting additional studies to better understand the mechanisms by which exposure to phthalates can affect pregnancy and to determine if there are effective ways for mothers to reduce their exposures.


Story Source:

Materials provided by NIH/National Institute of Environmental Health Sciences. Note: Content may be edited for style and length.


Journal Reference:

  1. Barrett M. Welch, Alexander P. Keil, Jessie P. Buckley, Antonia M. Calafat, Kate E. Christenbury, Stephanie M. Engel, Katie M. O'Brien, Emma M. Rosen, Tamarra James-Todd, Ami R. Zota, Kelly K. Ferguson, Akram N. Alshawabkeh, José F. Cordero, John D. Meeker, Emily S. Barrett, Nicole R. Bush, Ruby H. N. Nguyen, Sheela Sathyanarayana, Shanna H Swan, David E. Cantonwine, Thomas F. McElrath, Jenny Aalborg, Dana Dabelea, Anne P. Starling, Russ Hauser, Carmen Messerlian, Yu Zhang, Asa Bradman, Brenda Eskenazi, Kim G. Harley, Nina Holland, Michael S. Bloom, Roger B. Newman, Abby G. Wenzel, Joseph M. Braun, Bruce P. Lanphear, Kimberly Yolton, Pam Factor-Litvak, Julie B. Herbstman, Virginia A. Rauh, Erma Z. Drobnis, Amy E. Sparks, J. Bruce Redmon, Christina Wang, Alexandra M. Binder, Karin B. Michels, Donna D. Baird, Anne Marie Z. Jukic, Clarice R. Weinberg, Allen J. Wilcox, David Q. Rich, Barry Weinberger, Vasantha Padmanabhan, Deborah J. Watkins, Irva Hertz-Picciotto, Rebecca J. Schmidt. Associations Between Prenatal Urinary Biomarkers of Phthalate Exposure and Preterm Birth. JAMA Pediatrics, 2022; DOI: 10.1001/jamapediatrics.2022.2252

Cite This Page:

NIH/National Institute of Environmental Health Sciences. "Preterm birth more likely with exposure to phthalates." ScienceDaily. ScienceDaily, 11 July 2022. <www.sciencedaily.com/releases/2022/07/220711111854.htm>.
NIH/National Institute of Environmental Health Sciences. (2022, July 11). Preterm birth more likely with exposure to phthalates. ScienceDaily. Retrieved June 23, 2024 from www.sciencedaily.com/releases/2022/07/220711111854.htm
NIH/National Institute of Environmental Health Sciences. "Preterm birth more likely with exposure to phthalates." ScienceDaily. www.sciencedaily.com/releases/2022/07/220711111854.htm (accessed June 23, 2024).

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