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New antioxidants found in beef, chicken, and pork

Establishment of a highly sensitive detection method for imidazole dipeptide oxidation derivatives

February 17, 2023
Osaka Metropolitan University
Scientists found that 2-oxo-imidazole-containing dipeptides (2-oxo-IDPs) exhibit very high antioxidant activity. Furthermore, they established a method to selectively and sensitively detect very small amounts of 2-oxo-IDPs and revealed for the first time that several types of 2-oxo-IDPs are contained in meat, including beef, pork, and chicken.


Imidazole dipeptides (IDPs), which are abundant in meat and fish, are substances produced in the bodies of various animals, including humans, and have been reported to be effective in relieving fatigue and preventing dementia. However, the physiological mechanism by which IDPs exhibit these activities had not been determined previously.

A research team, led by Professor Hideshi Ihara from the Osaka Metropolitan University Graduate School of Science, was the first to discover 2-oxo-imidazole-containing dipeptides (2-oxo-IDPs) -- which have one more oxygen atom than normal IDPs -- and found that they are the most common variety of IDPs derivatives in the body. The researchers also found that they have remarkably high antioxidant activity.

In their study, the researchers established a method for selective and highly sensitive detection of five types of 2-oxo-IDPs using mass spectrometry, which enables quantitative detection of trace 2-oxo-IDPs in living organisms. Using this method, they revealed for the first time that beef, pork, chicken, and other meats contain antioxidants, not only IDPs but a variety of different 2-oxo-IDPs. Their findings were published in Antioxidants.

"We hope that this research method, which enables advanced analysis of 2-oxo-IDPs, will be applied not only to basic biology but also to medicine, agriculture, and pharmacy, where it will help improve peoples' health and prevent diseases," concluded Professor Ihara.


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Materials provided by Osaka Metropolitan University. Note: Content may be edited for style and length.

Journal Reference:

  1. Somei Komae, Shingo Kasamatsu, Koji Uchida, Hideshi Ihara. Quantitative Determination of 2-Oxo-Imidazole-Containing Dipeptides by High-Performance Liquid Chromatography/Tandem Mass Spectrometry. Antioxidants, 2022; 11 (12): 2401 DOI: 10.3390/antiox11122401

Cite This Page:

Osaka Metropolitan University. "New antioxidants found in beef, chicken, and pork." ScienceDaily. ScienceDaily, 17 February 2023. <>.
Osaka Metropolitan University. (2023, February 17). New antioxidants found in beef, chicken, and pork. ScienceDaily. Retrieved September 23, 2023 from
Osaka Metropolitan University. "New antioxidants found in beef, chicken, and pork." ScienceDaily. (accessed September 23, 2023).

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