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New potential drug target for Alzheimer's disease

Rensselaer researchers find new potential drug target for Alzheimer's disease

Date:
May 24, 2023
Source:
Rensselaer Polytechnic Institute
Summary:
Tau protein is implicated in many neurogenerative diseases, including Alzheimer's. New findings point to a new potential drug target to slow the progress of the disease: the enzymes responsible for sulfation called heparan sulfate 3-O transferases.
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Chunyu Wang, Ph.D., professor of biological sciences at Rensselaer Polytechnic Institute, has added to his body of research on Alzheimer's disease with significant findings in Angewandte Chemie.

Together with his team, which includes first author and Rensselaer doctoral student Dylan Mah, Wang performed the most comprehensive study to date of the interactions between ApoE, or Apolipoprotein E, and heparan sulfate (HS). ApoE is a protein that combines with fats to transport cholesterol throughout the body. Heparan sulfate is a sugar molecule present on cell surfaces that plays a key role in cellular communication. A variant of ApoE, ApoE4, is the most significant genetic risk for late-onset Alzheimer's disease.

"It's tremendously interesting to explore why ApoE4 can increase Alzheimer's risk," said Wang.

Wang's team investigated not only ApoE4, but ApoE3, the most common ApoE genotype and two protective isoform ApoE2 and ApoE Christchurch, as well. They discovered that the 3-O-sulfo (3-O-S) modification of HS was important for ApoE/HS interactions. All isoforms of ApoE recognized 3-O-S, but the differences in their strength of interactions correlated with Alzheimer's disease risk.

"In the initial glycan array experiment, which is basically a chip with a collection of different heparan sulfate oligosaccharide on it, we flowed ApoE over it," said Mah. "We were quite surprised to see that it had a binding pattern that looked very similar to Tau protein. It binds very well to the 3-O sulfated structures."

Tau protein is implicated in many neurogenerative diseases, including Alzheimer's.

The team's findings point to a new potential drug target to slow the progress of the disease: the enzymes responsible for sulfation called heparan sulfate 3-O transferases.

Next, the team plans to take a deeper look at ApoE/HS interaction by developing a 3D structural model of ApoE-HS interaction and examining this interaction in cell cultures and animal models.

"Alzheimer's disease is very complex with so many aspects," said Wang. "The more I study it, the more interesting it gets."

"Ultimately, we want to prevent or mitigate enough of the symptoms of Alzheimer's disease so people can continue to live independently," added Mah. "Understanding how the disease works on a molecular basis is really critical to finding new treatments."

"As our population ages, Dr. Wang's research on Alzheimer's disease is increasingly significant," said Deepak Vashishth, director of Rensselaer's Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies, of which Wang is a member. "The identification of a new potential drug target to fight this progressive disease is enormously exciting for not only the six million patients in the United States, but for their families and caregivers."

Wang and Mah were joined in research by Rensselaer Polytechnic Institute's Ashely Canning, James Gibson, Fuming Zhang, and Robert J. Linhardt. Yongmei Xu, Xuehong Song, and Lianchun Wang of the University of South Florida contributed, along with Guowei Su and Jian Liu of Glycan Therapeutics; Jing Zhao of China Agricultural University; and Yongmei Xu, Eduardo Stancanelli, and Jian Liu of University of North Carolina at Chapel Hill.


Story Source:

Materials provided by Rensselaer Polytechnic Institute. Original written by Katie Malatino. Note: Content may be edited for style and length.


Journal Reference:

  1. Dylan Mah, Yanan Zhu, Guowei Su, Jing Zhao, Ashely Canning, James Gibson, Xuehong Song, Eduardo Stancanelli, Yongmei Xu, Fuming Zhang, Robert J. Linhardt, Jian Liu, Lianchun Wang, Chunyu Wang. Apolipoprotein E Recognizes Alzheimer's Disease Associated 3‐ O Sulfation of Heparan Sulfate. Angewandte Chemie International Edition, 2023; DOI: 10.1002/anie.202212636

Cite This Page:

Rensselaer Polytechnic Institute. "New potential drug target for Alzheimer's disease." ScienceDaily. ScienceDaily, 24 May 2023. <www.sciencedaily.com/releases/2023/05/230524181929.htm>.
Rensselaer Polytechnic Institute. (2023, May 24). New potential drug target for Alzheimer's disease. ScienceDaily. Retrieved December 4, 2024 from www.sciencedaily.com/releases/2023/05/230524181929.htm
Rensselaer Polytechnic Institute. "New potential drug target for Alzheimer's disease." ScienceDaily. www.sciencedaily.com/releases/2023/05/230524181929.htm (accessed December 4, 2024).

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