Featured Research

from universities, journals, and other organizations

'Glowing' Transgenic Monkeys Carrying Green Fluorescent Protein Gene Pave Way For New Disease Models

Date:
May 28, 2009
Source:
Nature
Summary:
A transgenic line of monkeys carrying a gene encoding green fluorescent protein fully integrated into their DNA has been created for the first time. The research, published in the journal Nature, marks the first such feat in non-human primates and paves the way for developing new models of human diseases.

Five transgenic marmoset offspring are born, (a) Hisui, (b) Wakaba, (c) Banko, (d) Kei (left) and Kou (right). When observed in UV, the skin on the soles of the feet glow green.
Credit: E. Sasaki et al 2009

A transgenic line of monkeys carrying a gene encoding green fluorescent protein fully integrated into their DNA has been created for the first time. The research, published in the journal Nature, marks the first such feat in non-human primates and paves the way for developing new models of human diseases.

Scientists reported the first transgenic monkeys last year — a model of Huntington’s disease — but in these animals, the gene did not fully integrate into the monkey’s own DNA and was not passed down to their offspring. In this report, Erika Sasaki and colleagues used viral DNA as a delivery vehicle to introduce the gene for GFP into the DNA of the common marmoset Callithrix jacchus. They show that the gene integrated into the monkey’s DNA and was successfully passed down to their offspring, which were healthy and all expressed the new gene.

Transgenic mice have contributed immensely to biomedical research, but for many diseases they are too dissimilar from humans for the results to be meaningful. Non-human primates hold great promise for the study of several human diseases, particularly neurological disorders, for which there are currently no appropriate experimental models. This study marks an important milestone on the road to developing the means to investigate these diseases.

In an accompanying news story, Nature News reporter David Cyranoski explains why other transgenic monkeys have failed to reproduce so far, and describes the 5-year Japanese project to develop alternative animal models of which Sasaki’s research is a part. Also in this issue, an editorial calls for researchers working on transgenic primates to go much further than they have so far in articulating the ethical aspects both of their research and its potential applications. Engagement in public discussion is essential to avoid inappropriate regulation.


Story Source:

The above story is based on materials provided by Nature. Note: Materials may be edited for content and length.


Journal References:

  1. Sasaki et al. Generation of transgenic non-human primates with germline transmission. Nature, 2009; 459 (7246): 523 DOI: 10.1038/nature08090
  2. David Cyranoski. Marmoset model takes centre stage. Nature, 2009; 459 (7246): 492 DOI: 10.1038/459492a
  3. Gerald Schatten, Shoukhrat Mitalipov. Developmental biology: Transgenic primate offspring. Nature, 2009; 459 (7246): 515 DOI: 10.1038/459515a

Cite This Page:

Nature. "'Glowing' Transgenic Monkeys Carrying Green Fluorescent Protein Gene Pave Way For New Disease Models." ScienceDaily. ScienceDaily, 28 May 2009. <www.sciencedaily.com/releases/2009/05/090527215547.htm>.
Nature. (2009, May 28). 'Glowing' Transgenic Monkeys Carrying Green Fluorescent Protein Gene Pave Way For New Disease Models. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2009/05/090527215547.htm
Nature. "'Glowing' Transgenic Monkeys Carrying Green Fluorescent Protein Gene Pave Way For New Disease Models." ScienceDaily. www.sciencedaily.com/releases/2009/05/090527215547.htm (accessed September 22, 2014).

Share This



More Plants & Animals News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Raw: San Diego Zoo Welcomes Cheetah Cubs

Raw: San Diego Zoo Welcomes Cheetah Cubs

AP (Sep. 20, 2014) The San Diego Zoo has welcomed two Cheetah cubs to its Safari Park. The nearly three-week-old female cubs are being hand fed and are receiving around the clock care. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Chocolate Museum Opens in Brussels

Chocolate Museum Opens in Brussels

AFP (Sep. 19, 2014) Considered a "national heritage" in Belgium, chocolate now has a new museum in Brussels. In a former chocolate factory, visitors to the permanent exhibition spaces, workshops and tastings can discover derivatives of the cocoa bean. Duration: 01:00 Video provided by AFP
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins